Protein Alignment Irk1 and kcnj8

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_001025324.1
• Gene: kcnj8 / 561090
• ZFINID: ZDB-GENE-060308-1
• Length: 416
• Species: Danio rerio
• Alignment Length: 357
• Identity: 160/357 - (44%)
• Similarity: 229/357 - (64%)
• Gaps: 19/357 - (5%)

  Fly   120 VSESPGPLTRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLV 184
            ||..|      |:..|..|..:.|.:.|.|.||:...|: :.:.|:|||:||||||.:||:||::
Zfish    18 VSRVP------RKPVFRDRVNKARFIAKSGACNLAHKNI-REQGRFLQDVFTTLVDLKWRFTLVI 75

  Fly   185 FAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQ 249
            |..:|:.||..|...||::|:.|.||:    .::.|.:      ..|||.|::..||||:|:|.|
Zfish    76 FTMTFLCSWLLFAMSWWLVAFGHGDLD----TDRKPAV------EQCVTNVNSFTSAFLFSIEVQ 130

  Fly   250 TTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRD 314
            .|||:|.|.:||.||.||..:.:|.|.|:.|.|.|:|.:|.|.::..:||:||:|||:|||..|:
Zfish   131 VTIGFGGRMITERCPIAIAFLILQNIIGLIINAVMLGCIFMKTAQSHRRAETLIFSRHAVIAVRN 195

  Fly   315 GVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIV 379
            ...|.|.||||:|||.||.|.||.|::||.:|.||||:|..|.::...:....:.:..:.|..|.
Zfish   196 NRLCFMIRVGDLRKSMIINAVVRLQVVRKTMTPEGEVIPIQQIDVQTESAVAGNSIFLLAPLIIC 260

  Fly   380 HKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKE 444
            |.||::||||.|||.::.....||:|:||||:|:||:|||||:||:..|:.||||||.:|:  :|
Zfish   261 HVIDKDSPLYDLSAMELQCSDLEVIVILEGVVETTGITTQARTSYVTEEIQWGHRFVPIVT--EE 323

  Fly   445 TGEYEVDYTLFNNTYDVDTPLCSAKQLDELKS 476
            .|.|.|||:.|.||..|.||.|||::|||..|
Zfish   324 EGVYSVDYSKFGNTVKVATPRCSARELDEKPS 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	62/149 (42%)
		IRK_C	302..476	CDD:465439	87/173 (50%)
kcnj8	NP_001025324.1	IRK	37..175	CDD:460023	62/148 (42%)
		IRK_C	183..355	CDD:465439	87/173 (50%)