Protein Alignment Irk1 and kcnj5

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_031760961.1
• Gene: kcnj5 / 549655
• XenbaseID: XB-GENE-5919506
• Length: 440
• Species: Xenopus tropicalis
• Alignment Length: 365
• Identity: 182/365 - (49%)
• Similarity: 246/365 - (67%)
• Gaps: 15/365 - (4%)

  Fly   111 RQIRRSIKAVSESPGPLTRYRQTRFSS-RRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLV 174
            |:.::..|...|.| .||..|....|. ::.|:|.:.|.|:|||..||| |...||..|:|||||
 Frog    56 REPKKLPKQAREDP-TLTIDRTHLLSEHKKPRQRYMEKDGKCNVHHGNV-KETYRYFSDLFTTLV 118

  Fly   175 DAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMM 239
            |.:|.::|.:|...:..:|.|||.|||:|||...||::...||..|          ||..::..:
 Frog   119 DLKWHFSLFIFTLVYTVTWLFFGLIWWLIAYIRGDLDHLGDKNWVP----------CVENLNGFV 173

  Fly   240 SAFLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLF 304
            ||||:|:||:||||||.|.:||:|||.|..:.:|.|.|..:.|.|||.:|.|:|:|||||:||:|
 Frog   174 SAFLFSIETETTIGYGYRVITEKCPEGIVLLLVQAILGSIVNALMVGCMFVKISQPKKRAETLMF 238

  Fly   305 SRNAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDR 369
            |.||||..|||..||||||||:|.|||:||.:||::|:.|.|||||.:|..|.::::|.|.|:||
 Frog   239 SNNAVISLRDGKLCLMFRVGDLRSSHIVEASIRAKLIKSKQTKEGEFIPLNQTDINVGFDTGDDR 303

  Fly   370 LMFIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHR 434
            |..:.|..|.|:|:..||.:.:|.:.|..|.||:||:|||::|:||||.|||.||:.||||||||
 Frog   304 LFLVSPLIISHEINEKSPFWEMSRTQMDIEEFEIVVILEGMVEATGMTCQARCSYVDSEVLWGHR 368

  Fly   435 FVNVVSFRKETGEYEVDYTLFNNTYDVDTPLCSAKQLDEL 474
            |..|::..|  |.||||||.|::||:..||.||||:||||
 Frog   369 FTPVLTLEK--GFYEVDYTSFHDTYETPTPSCSAKELDEL 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	68/149 (46%)
		IRK_C	302..476	CDD:465439	98/173 (57%)
kcnj5	XP_031760961.1	IRK	90..229	CDD:460023	68/149 (46%)
		IRK_C	236..405	CDD:465439	95/170 (56%)