Protein Alignment Irk1 and kcnj11l

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_001012387.1
• Gene: kcnj11l / 497647
• ZFINID: ZDB-GENE-050222-2
• Length: 432
• Species: Danio rerio
• Alignment Length: 353
• Identity: 164/353 - (46%)
• Similarity: 231/353 - (65%)
• Gaps: 15/353 - (4%)

  Fly   127 LTRYRQ----TRFSSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAA 187
            |||..:    :|...:..|.|.:.|.|.|||...|: :.:.|:|||:|||:||.:|:.:||:|.:
Zfish    14 LTRLAEDAQPSRIRPKSQRARFITKSGSCNVAHKNI-REQGRFLQDVFTTMVDLKWQHSLLIFTS 77

  Fly   188 SFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTI 252
            :|:.||..|..:||::|:||.|||..:.....|        ..|||.:.:..||||:|:|.|.||
Zfish    78 AFLCSWMLFAMVWWLLAFAHGDLEPRDPNEPGP--------VPCVTSIHSFTSAFLFSIEVQVTI 134

  Fly   253 GYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVP 317
            |:|.|.||||||.||..:.||.|.|:.|.|.|:|.||.|.::..:||:||:|||||||..|:|.|
Zfish   135 GFGGRMVTEECPLAIIVLIIQNILGLIINAIMLGCVFMKTAQANRRAETLIFSRNAVIAPRNGRP 199

  Fly   318 CLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKI 382
            .|||||||:|||.||.|:::.|:||:.||.||||:|..|.::.:......:.:..:.|..|.|.|
Zfish   200 TLMFRVGDLRKSMIISANIQLQVIRRTVTAEGEVIPVCQLDIQVENPLRSNGIFLVSPLIISHTI 264

  Fly   383 DRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGE 447
            ||.||||.|||..|..|..|::|:||||:|:||:|.|||:||:|.|:|||.|||::::  :|.|.
Zfish   265 DRGSPLYELSAQSMATEDLEIIVILEGVVETTGITMQARTSYIPEEILWGRRFVSIMT--EEDGR 327

  Fly   448 YEVDYTLFNNTYDVDTPLCSAKQLDELK 475
            |.|||:.|.||..|..|..|||:||:.:
Zfish   328 YSVDYSKFGNTVPVRMPALSAKELDQTR 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	66/149 (44%)
		IRK_C	302..476	CDD:465439	89/174 (51%)
kcnj11l	NP_001012387.1	IRK	36..177	CDD:460023	66/149 (44%)
		IRK_C	184..353	CDD:465439	88/170 (52%)