DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irk1 and Irk2

DIOPT Version :9

Sequence 1:	NP_001262861.1	Gene:	Irk1 / 42742	FlyBaseID:	FBgn0265042	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	230/461 - (49%)
Similarity:	289/461 - (62%)	Gaps:	43/461 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 TSTYASNINSTGGESSGSGTQLSRK---------ESILG---SFHRQI----RRSIKAVSESPGP 126
            ::|..:...:.|||.:   ||..:|         :|::.   |:...|    ..|...:|::..|
  Fly    14 STTIPTTTQANGGEQA---TQPLKKAIEADPDSLDSVISNPQSYPITIVPNRPTSYYGLSQNGKP 75

  Fly   127 LTRY---RQTRF---SSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVF 185
            ..|.   |...|   |.||||:|.|||:|:|||||.::.:||.|:|||::||:||.|||||||.|
  Fly    76 FPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAF 140

  Fly   186 AASFVFSWAFFGFIWWIIAYAHNDLEYTNL-KNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQ 249
            |.||:.||.||..|||:|.|.|.|||..:| :||.....|     .||:.:....|.||:|:|||
  Fly   141 ALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWA-----PCVSAIDGFTSCFLFSIETQ 200

  Fly   250 TTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRD 314
            .|||||.|..:.|||||||.||.|.|.||...|||.||||||::|.|:||||||||::||||.||
  Fly   201 HTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRD 265

  Fly   315 GVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIV 379
            |...||||||||||||||.|.||||:||.|.||||||:..|..||.||.|.....|.||||..|.
  Fly   266 GTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIE 330

  Fly   380 HKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKE 444
            ||||.|||||.|:|:|||:::||:||:|||.:||||.:|||||||:.:|:||||||..||.:.|:
  Fly   331 HKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKD 395

  Fly   445 TGEYEVDYTLFNNTYDVDTPLCSAKQLDELKSEYSKSAKCVNAPFADRTLSASLFQRIASAASVD 509
            ...||:||..||.|..||||||||::|:|:..............|..|.||.            :
  Fly   396 LQAYEIDYARFNETTQVDTPLCSARELNEIYKIQEGFRTPAETTFTMRQLSH------------N 448

  Fly   510 HLDPAS 515
            |.|.||
  Fly   449 HSDQAS 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..477	CDD:279361	200/332 (60%)
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	200/338 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449123
Domainoid	1	1.000	195	1.000	Domainoid score	I3095
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2116
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000937
OrthoInspector	1	1.000	-	-		mtm6393
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	P	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
	9	8.890