Protein Alignment Irk1 and KCNJ3

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_002230.1
• Gene: KCNJ3 / 3760
• HGNCID: 6264
• Length: 501
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 197/554 - (35%)
• Similarity: 276/554 - (49%)
• Gaps: 114/554 - (20%)

  Fly    73 DTYKRTSTYASNINSTGGESSGSGTQLSRKESILGSFHRQIRRSIKAVSESPGPLTRYRQTRFSS 137
            |.|:..:|          .|||||.|                      .:.||   :..|.:...
Human    10 DDYQVVTT----------SSSGSGLQ----------------------PQGPG---QDPQQQLVP 39

  Fly   138 RRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWI 202
            ::.|:|.|.|:|.|||..||:.....|||.|:||||||.:|||.|.:|..::..:|.|...:||:
Human    40 KKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWV 104

  Fly   203 IAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAI 267
            |||...||...::.|.:|          ||..|.|..||||:.:||:.|||||.||:|::|||.|
Human   105 IAYTRGDLNKAHVGNYTP----------CVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGI 159

  Fly   268 FTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHII 332
            .....|.|.|..:.||::|.:|.|:|:|||||:||:||.:|||..|||...||||||::|.||::
Human   160 ILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMV 224

  Fly   333 EAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDML 397
            .|.:|.::::.:.|.|||.||..|.||.:|...|.|:|..:.|.||.|.||..||.|.||...|.
Human   225 SAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQ 289

  Fly   398 KERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDVD 462
            .|:||:||:|||::|:||||.|||:||...||||||||..|:|.  |.|.::|||:.|:.|::|.
Human   290 TEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISL--EEGFFKVDYSQFHATFEVP 352

  Fly   463 TPLCSAKQLDEL--------------KSEYSKSAKCVNA-------------------PFADRTL 494
            ||..|.|:.:|:              ..|...|.:|::.                   .|..:.|
Human   353 TPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLL 417

  Fly   495 SAS---------------LFQRIASAASVDHLDPASDESLDSGRLQIRSHSIPNGVLASELEPLN 544
            ..|               ..|||:|...      .|:|.|.|...::.|..:...|  ::|.|..
Human   418 RMSSTTSEKAYSLGDLPMKLQRISSVPG------NSEEKLVSKTTKMLSDPMSQSV--ADLPPKL 474

  Fly   545 NNKHGASFTMGGLTITTTAPSIPNLSSINEKTNS 578
            ....|.:..|.|           ||.:...|.||
Human   475 QKMAGGAARMEG-----------NLPAKLRKMNS 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	65/149 (44%)
		IRK_C	302..476	CDD:465439	86/187 (46%)
KCNJ3	NP_002230.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		12/64 (19%)
		IRK	47..187	CDD:460023	65/149 (44%)
		Selectivity filter. /evidence=ECO:0000250	143..148		4/4 (100%)
		Polyphosphoinositide (PIP2)-binding. /evidence=ECO:0000250|UniProtKB:P63251	182..209		17/26 (65%)
		IRK_C	194..364	CDD:465439	85/171 (50%)