DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irk1 and KCNJ1

DIOPT Version :10

Sequence 1:NP_001262861.1 Gene:Irk1 / 42742 FlyBaseID:FBgn0265042 Length:652 Species:Drosophila melanogaster
Sequence 2:NP_000211.1 Gene:KCNJ1 / 3758 HGNCID:6255 Length:391 Species:Homo sapiens


Alignment Length:354 Identity:159/354 - (44%)
Similarity:228/354 - (64%) Gaps:13/354 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 IKAVSESP-GPLTRYRQTR-FSSRRVRKRVVFKHGECNVVQGNV-AKRRRRYLQDIFTTLVDAQW 178
            |:.::||. ..|.::..|| |...|.|.|:|.|.|.||:..||| |:.|..:..||:||::|.:|
Human    13 IRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKW 77

  Fly   179 RWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFL 243
            |:.:.:|..:|:.||.|||.:|:.:||.|.||         |:...:..||.||..::.:.||||
Human    78 RYKMTIFITAFLGSWFFFGLLWYAVAYIHKDL---------PEFHPSANHTPCVENINGLTSAFL 133

  Fly   244 YSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNA 308
            :|:|||.|||||.|.|||:|..|||.:..|.|.||.|.:||.|.:.||:|||||||:|:.||:||
Human   134 FSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNA 198

  Fly   309 VICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFI 373
            ||..|.|..||:.||.::|||.:|.:|:..::::..||.|||.:...|..::...|.|.:.|.||
Human   199 VISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFI 263

  Fly   374 WPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNV 438
            .|.||.|.||.|||.:.::|..:|::.||:||.|:|.:|||..|.|.|:||:|.|||||:||..:
Human   264 SPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPI 328

  Fly   439 VSFRKETGEYEVDYTLFNNTYDVDTPLCS 467
            ||..|| |:|.||:..|:.|.:|:||.|:
Human   329 VSKTKE-GKYRVDFHNFSKTVEVETPHCA 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irk1NP_001262861.1 IRK 145..295 CDD:460023 67/150 (45%)
IRK_C 302..476 CDD:465439 75/166 (45%)
KCNJ1NP_000211.1 IRK 43..185 CDD:460023 67/150 (45%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472 141..146 4/4 (100%)
Polyphosphoinositide (PIP2)-binding. /evidence=ECO:0000250|UniProtKB:P35560 180..207 18/26 (69%)
IRK_C 192..364 CDD:465439 75/166 (45%)

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