DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irk1 and Kcnj2

DIOPT Version :10

Sequence 1:NP_001262861.1 Gene:Irk1 / 42742 FlyBaseID:FBgn0265042 Length:652 Species:Drosophila melanogaster
Sequence 2:NP_058992.1 Gene:Kcnj2 / 29712 RGDID:61968 Length:427 Species:Rattus norvegicus


Alignment Length:381 Identity:182/381 - (47%)
Similarity:256/381 - (67%) Gaps:18/381 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 GTQLSRKESILGSFHRQIRRSIKAVSESPGPLTRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAK 160
            |:..:.:.||:.|....::.:..||:...|.......||   ::.|.|.|.|.|.|||...||.:
  Rat     2 GSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTR---QQCRSRFVKKDGHCNVQFINVGE 63

  Fly   161 RRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVAN 225
            :.:|||.|||||.||.:|||.|::|..:||.||.|||.::|:||..|.||:            |:
  Rat    64 KGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLD------------AS 116

  Fly   226 ITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFA 290
            .....||::|::..:|||:|:|||||||||.|.||:|||.|:|.:..|.|.|..|.||::|.|.|
  Rat   117 KESKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMA 181

  Fly   291 KLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFY 355
            |:::||||.:||:||.||||..|||..|||:|||::||||::|||||||:::.::|.|||.:|..
  Rat   182 KMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLD 246

  Fly   356 QQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQA 420
            |.::::|.|.|.||:..:.|.||||:||.:||||.||..|:....||:||:|||::|:|.||||.
  Rat   247 QIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQC 311

  Fly   421 RSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDV-DTPLCSAKQLDELK 475
            |||||.:|:|||||:..|:...|..  |:|||:.|:.||:| :||||||:.|.|.|
  Rat   312 RSSYLANEILWGHRYEPVLFEEKHC--YKVDYSRFHKTYEVPNTPLCSARDLAEKK 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irk1NP_001262861.1 IRK 145..295 CDD:460023 71/149 (48%)
IRK_C 302..476 CDD:465439 95/175 (54%)
Kcnj2NP_058992.1 IRK_N 1..47 CDD:462486 10/47 (21%)
IRK 48..186 CDD:460023 71/149 (48%)
Selectivity filter. /evidence=ECO:0000250 142..147 4/4 (100%)
Polyphosphoinositide (PIP2)-binding. /evidence=ECO:0000269|PubMed:9486652 181..208 17/26 (65%)
IRK_C 193..366 CDD:465439 95/175 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..427
PDZ-binding. /evidence=ECO:0000255 425..427
Blue background indicates that the domain is not in the aligned region.

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