Protein Alignment Irk1 and irk-1

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_509138.2
• Gene: irk-1 / 180944
• WormBaseID: WBGene00002149
• Length: 544
• Species: Caenorhabditis elegans
• Alignment Length: 543
• Identity: 210/543 - (38%)
• Similarity: 309/543 - (56%)
• Gaps: 62/543 - (11%)

  Fly    70 CLEDTYKRTSTYAS-NINSTGGESSGSGTQLSRKESILGSFHRQIRRSIKAVSESPGPLTRYRQT 133
            |.|....|.|.:.. ::.|....::|..:...|:.|:..|    ||........:..||  ||:
 Worm     8 CAEMNRIRMSNHRKMSLGSAPLIANGRPSPPPRRTSLAES----IRTLAFTARRNSSPL--YRK- 65

  Fly   134 RFSSRRVRK-RVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFG 197
              |:::::| |:|.|:|.|||...||.|:.|:||:|||||::|.:|||.|::||::||.||:.||
 Worm    66 --STKKLKKSRLVGKNGICNVYNTNVPKKDRQYLRDIFTTMIDVKWRWMLMLFASAFVLSWSIFG 128

  Fly   198 FIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEE 262
            ..:::||..|.||          .|...:.||.||..:.::.|:||::|||..|||||:||:|.|
 Worm   129 TTYYLIALVHGDL----------SLPTPVNHTACVMNLDSVYSSFLFAVETHHTIGYGHRYITTE 183

  Fly   263 CPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMR 327
            |..|...:|:|.|..:.:|:|||||||||::||||||:|::||..||||.|||..|.:.||||||
 Worm   184 CYLAGAIVCLQAICALLLQSFMVGIVFAKMARPKKRAETIIFSDKAVICLRDGQLCFLCRVGDMR 248

  Fly   328 KSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIG---ADGGEDRLMFIWPTTIVHKIDRNSPLY 389
            .:|::|||||.|.|..:.|.|||:.|.:|.|:.:|   ||  :|||..:||||:.|.||..||||
 Worm   249 NTHLVEAHVRLQFITDRETNEGEIEPLHQFEMKVGPSIAD--DDRLFLVWPTTLCHVIDSRSPLY 311

  Fly   390 MLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTL 454
            ..:...::..:||::|:|||::||||||.||::|||||||||||||..:|::::..|.|::||.|
 Worm   312 NYNQQTLMSAQFEIIVLLEGIVESTGMTAQAKTSYLPSEVLWGHRFRKLVTYQRSNGSYQIDYDL 376

  Fly   455 FNNTYDVDTPLCSAKQL----DELKSEYSKSAKCVNAPFADRTLSASLFQRIASAASVDHLDPAS 515
            |::||.|.||..|..:.    ..||..|...:.       :..|..:   |.:.:..:....|.|
 Worm   377 FHSTYPVRTPAMSPAEFYSSKPNLKDYYCHDSH-------EHKLEDN---RSSDSTPLPSPSPYS 431

  Fly   516 DESLDSGRLQIRSHSIPNGVLASELEPLNNNKHGASFT------MGGL---TITTTAPSIPNLSS 571
            ..|......|..|:|           |:.:|.|....|      .|.|   ||....||  ..:|
 Worm   432 YPSTPLNHFQSSSNS-----------PVFSNNHSKFNTEAVTCEAGMLCPPTIVVQCPS--TCAS 483

  Fly   572 INEKTNSGNSINSSNYSNNNSLS 594
            .|....:.|.::.|..|::..|:
 Worm   484 PNHMRRTRNQMDKSRTSSSCDLT 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	70/149 (47%)
		IRK_C	302..476	CDD:465439	89/180 (49%)
irk-1	NP_509138.2	IRK	76..216	CDD:460023	70/149 (47%)
		IRK_C	223..386	CDD:465439	85/164 (52%)