Protein Alignment Irk1 and Kcnj3

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_032452.1
• Gene: Kcnj3 / 16519
• MGIID: 104742
• Length: 501
• Species: Mus musculus
• Alignment Length: 510
• Identity: 192/510 - (37%)
• Similarity: 278/510 - (54%)
• Gaps: 73/510 - (14%)

  Fly    73 DTYKRTSTYASNINSTGGESSGSGTQLSRKESILGSFHRQIRRSIKAVSESPGPLTRYRQTRFSS 137
            |.|:..:|          .|||||.|                      .:.||   :..|.:...
Mouse    10 DDYQVVTT----------SSSGSGLQ----------------------PQGPG---QGPQQQLVP 39

  Fly   138 RRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWI 202
            ::.|:|.|.|:|.|||..||:.....|||.|:||||||.:|||.|.:|..::..:|.|...:||:
Mouse    40 KKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWV 104

  Fly   203 IAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAI 267
            |||...||...::.|.:|          ||..|.|..||||:.:||:.|||||.||:|::|||.|
Mouse   105 IAYTRGDLNKAHVGNYTP----------CVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGI 159

  Fly   268 FTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHII 332
            .....|.|.|..:.||::|.:|.|:|:|||||:||:||.:|||..|||...||||||::|.||::
Mouse   160 ILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMV 224

  Fly   333 EAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDML 397
            .|.:|.::::.:.|.|||.||..|.||.:|...|.|:|..:.|.||.|.||..||.|.||...|.
Mouse   225 SAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQ 289

  Fly   398 KERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDVD 462
            .|:|||||:|||::|:||||.|||:||...||||||||..|:|.  |.|.::|||:.|:.|::|.
Mouse   290 TEQFEVVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISL--EEGFFKVDYSQFHATFEVP 352

  Fly   463 TPLCSAKQLDELKSEYSKSAKCVNAPFADRTLSASLFQRIASAASVDHLDPASDESLDSGRLQIR 527
            ||..|.|:.:|:        ..:::|.....::.|. :|..|...:|.||..|.: |.|...:|.
Mouse   353 TPPYSVKEQEEM--------LLMSSPLIAPAITNSK-ERHNSVECLDGLDDISTK-LPSKLQKIT 407

  Fly   528 S-HSIPNGVLASELEPLNNNKHGASFTMGGLTITTTAPSIPNLSSINEKTNSGNS 581
            . ...|..:|.     :::.....::::|.|.:     .:..:||:     .|||
Mouse   408 GREDFPKKLLR-----MSSTTSEKAYSLGDLPM-----KLQRISSV-----PGNS 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	65/149 (44%)
		IRK_C	302..476	CDD:465439	87/173 (50%)
Kcnj3	NP_032452.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		12/64 (19%)
		IRK	47..187	CDD:460023	65/149 (44%)
		Selectivity filter. /evidence=ECO:0000250	143..148		4/4 (100%)
		Polyphosphoinositide (PIP2)-binding. /evidence=ECO:0000250|UniProtKB:P63251	182..209		17/26 (65%)
		IRK_C	194..364	CDD:465439	86/171 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..501