Protein Alignment Irk1 and Kcnj12

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_034733.4
• Gene: Kcnj12 / 16515
• MGIID: 108495
• Length: 529
• Species: Mus musculus
• Alignment Length: 591
• Identity: 118/591 - (19%)
• Similarity: 203/591 - (34%)
• Gaps: 170/591 - (28%)

  Fly    25 PLRIK----VVAGLQ--LAKKDIFGASDPYVRIDVNQISG-DATVLSKFTKTKKRTLHPKWNEEF 82
            |.|:|    |.:|.|  |:...|.|..:     .:.||.| |:::|.::..|.|:.   ..|...
Mouse  1189 PFRMKQGSVVSSGSQVLLSSLTIDGVCE-----KLRQIQGLDSSMLEQYIGTIKKA---NVNGRV 1245

  Fly    83 ILRVNPAEHK----------------LVLQVFDENRLTRDDFLGMVELSLDQLPKERPGVEIPIR 131
            :.:.|..|.|                :|.|...||:|..|:.....|          .|..:.|:
Mouse  1246 LSQCNLDELKKEMNMNFGDWHLFRSTVVEQRHAENQLLHDESGACSE----------QGSSVLIQ 1300

  Fly   132 SYPLRPRSARSN--VRGELQLYHAFIVDQDSNETDWEMVDSNPVPSVSRSQSANSVASTPR---- 190
            ..|.||..||.:  |..|...|        |....:|.:....:...:|..:|:.:|:|.|
Mouse  1301 PEPHRPSEARQDVTVNPENFTY--------SLNLSFEELSGVGLEESARQHNAHWLANTHRTPSL 1357

  Fly   191 -SSTSNAAAFELPQGWEERQDANGRTY--YVNHVA--------RSTQWERPTAVPM-----EAIA 239
             |..|..::.::.:..:::|......|  |::|::        |.:|.:..::..:     :.|.
Mouse  1358 SSLNSQESSNDICKLTDKQQAEYHSAYQEYISHMSHLEASAAGRESQTQALSSQLLSTSSEDKIK 1422

  Fly   240 ESDMD--VAFQRR----VHISVDDSATSDTGSVG--------SDLAALQLNTSRSNSLVSASNG- 289
            |.|.|  ..|.::    .....|.|:..|:|.:.        ||..:...|..|..   :...|
Mouse  1423 EGDQDGRKPFGKKGPKPTDTMADFSSPPDSGLLDPITEEDEKSDHGSATKNPPRRK---TKGQGP 1484

  Fly   290 ---SLASSARPDGSAEKESTHTVVLRSGAAPAQSAHRHLSTPPRLPAALVRSSTRAVPIPGRAAA 351
               ||.|.  .|.|.::|:..|.:|:.....|:....|||
Mouse  1485 YYHSLPSD--EDDSGDEETDATPLLKDEPWGAEPDLDHLS------------------------- 1522

  Fly   352 ALNRSRFENGENGGVQLRSSAHLADGGRRSSSRSSIGSDSSLRAQQRAAIDAADEDMHHNNNNNG 416
                    .|:.....:......:|.|.| |||||  ||.||:          ||:....:....
Mouse  1523 --------KGKGFVSDIMLDKKSSDSGVR-SSRSS--SDHSLQ----------DEEKEEKSEEQE 1566

  Fly   417 GTFGTGATHG-------SNSINNNDTSDDRSSTRSSTSNENDSSGSSPSTGGGAGSMTLPAGWSM 474
            ..........       .|.::|   ..|.:..|.|..::..|.||:|..     |...||..::
Mouse  1567 AQLIELVVESPVKKRVLPNRLSN---LQDEALARMSICSDAPSEGSTPEE-----SWPAPAVSNL 1623

  Fly   475 QLAPN-----------GRVFFIDHNERKTSWVDPRTGRASPMPTSQGSAALSDVRRPEDGLAPLP 528
            ..:.|           |:...:|..:..:..:.|   .:|...|:..:..|..|:| :..:.|..
Mouse  1624 NCSANNTAINNNINNSGQQETLDSTDCPSLIIRP---GSSTENTTLENQNLRGVQR-KMSIGPAT 1684

  Fly   529 EGWEER 534
            :..|||
Mouse  1685 DATEER 1690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	34/187 (18%)
		IRK_C	302..476	CDD:465439	34/180 (19%)
Kcnj12	NP_034733.4	FAM222A	<24..>117	CDD:464598
		IRK_N	104..148	CDD:462486
		IRK	149..289	CDD:460023
		IRK_C	296..468	CDD:465439