DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irk1 and Kcnj4

DIOPT Version :10

Sequence 1:NP_001262861.1 Gene:Irk1 / 42742 FlyBaseID:FBgn0265042 Length:652 Species:Drosophila melanogaster
Sequence 2:NP_446322.2 Gene:Kcnj4 / 116649 RGDID:621436 Length:446 Species:Rattus norvegicus


Alignment Length:446 Identity:200/446 - (44%)
Similarity:275/446 - (61%) Gaps:41/446 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 TRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFS 192
            :|..|.....|:.|.|.|.|:|:|||...|::.:.:||:.|||||.||.:||:.|::|:|:|:.|
  Rat     5 SRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVS 69

  Fly   193 WAFFGFIWWIIAYAHNDLEYTNLKNQSPD------------LVANITHTVCVTQVSNMMSAFLYS 245
            |.|||.::|.||:.|.|||      .||.            ..|......|:..|:..:.|||:|
  Rat    70 WLFFGLLFWCIAFFHGDLE------PSPSGPTAGGPGGNGGGAAPTAAKPCIMHVNGFLGAFLFS 128

  Fly   246 VETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVI 310
            ||||||||||.|.||||||.|:..:.:|.|.|..|.:||:|.:.||::||||||||||||.:|||
  Rat   129 VETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVI 193

  Fly   311 CHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWP 375
            ..|||..|||:|||::|||||:|||||||:|:..:|:|||.||..|::|::|.|.|.||:..:.|
  Rat   194 SVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSP 258

  Fly   376 TTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVS 440
            ..|||:||.:||||.:...::..|.||:||:|||::|:|.||||||||||.||:||||||..||.
  Rat   259 IIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVF 323

  Fly   441 FRKETGEYEVDYTLFNNTYDV-DTPLCSAKQLDELKSEY------SKSAKCVNAPFADRTLSASL 498
              :|...|:|||:.|:.||:| .||.|||::|.|.|...      ..||.|.....|..:.....
  Rat   324 --EEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEE 386

  Fly   499 FQRIASAASVDHLDPASDESLDSG---------RLQIRSHSIPNGVLASELEPLNN 545
            .:..|:||:.    .|:...|::|         .|:..||.....:.|:.| ||:|
  Rat   387 MEEEAAAAAA----VAAGLGLEAGSKEETGIIRMLEFGSHLDLERMQAATL-PLDN 437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irk1NP_001262861.1 IRK 145..295 CDD:460023 70/161 (43%)
IRK_C 302..476 CDD:465439 98/174 (56%)
Kcnj4NP_446322.2 IRK 22..178 CDD:460023 70/161 (43%)
Val/Gly/Ala/Pro stretch 91..111 2/19 (11%)
Selectivity filter. /evidence=ECO:0000250 134..139 4/4 (100%)
IRK_C 185..357 CDD:465439 98/173 (57%)
PDZ-binding. /evidence=ECO:0000255 444..446
Blue background indicates that the domain is not in the aligned region.

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