Protein Alignment Irk1 and kcnj6

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_031752409.1
• Gene: kcnj6 / 116408751
• XenbaseID: XB-GENE-959134
• Length: 405
• Species: Xenopus tropicalis
• Alignment Length: 380
• Identity: 189/380 - (49%)
• Similarity: 259/380 - (68%)
• Gaps: 29/380 - (7%)

  Fly   113 IRRSI---KAVSESPGPLTRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLV 174
            ||:.|   |...|.||     || :.|.|:: :|.|.|.|:|||..||| :...|:|.|||||||
 Frog    11 IRQPIKLPKQAREDPG-----RQ-KCSKRKI-QRYVRKDGKCNVHHGNV-RETYRFLSDIFTTLV 67

  Fly   175 DAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMM 239
            |.:||:.||:|...:..:|.|||||||:|||...|||:...|..:|          ||..::..:
 Frog    68 DLKWRFNLLIFVMVYTATWLFFGFIWWLIAYIRGDLEHIGDKKWNP----------CVDNLNGFV 122

  Fly   240 SAFLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLF 304
            ||||:|:||:||||||.|.:|::|||.|..:.:|.:.|..:.|||||.:|.|:|:|||||:||:|
 Frog   123 SAFLFSIETETTIGYGYRVITDKCPEGIVLLLVQSVLGSIVNAFMVGCMFVKISQPKKRAETLVF 187

  Fly   305 SRNAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDR 369
            |.||||..|||..||||||||:|.|||:||.:||::|:.|.|||||.:|..|.::::|.|.|:||
 Frog   188 STNAVISMRDGRLCLMFRVGDLRNSHIVEASIRAKLIKSKQTKEGEFIPLNQTDINVGYDTGDDR 252

  Fly   370 LMFIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHR 434
            |..:.|..|.|:|:.:||.:.:|.:.:.||.||:||:|||::|:||||.||||||:.||:|||||
 Frog   253 LFLVSPLIISHEINAHSPFWEISKAQLPKEDFEIVVILEGMVEATGMTCQARSSYITSEILWGHR 317

  Fly   435 FVNVVSFRKETGEYEVDYTLFNNTYDVDTPLCSAKQLDELKS------EYSKSAK 483
            |..|::.  |.|.|||||..|::||:.:||.||||:|.||.|      .:|.|:|
 Frog   318 FTPVLTL--EDGFYEVDYNSFHDTYETNTPSCSAKELAELVSRTEIPLSWSVSSK 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	71/149 (48%)
		IRK_C	302..476	CDD:465439	96/173 (55%)
kcnj6	XP_031752409.1	IRK	39..178	CDD:460023	71/149 (48%)
		IRK_C	185..354	CDD:465439	94/170 (55%)