Protein Alignment Irk1 and kcnj14

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_073780606.1
• Gene: kcnj14 / 100526806
• ZFINID: ZDB-GENE-100922-48
• Length: 543
• Species: Danio rerio
• Alignment Length: 489
• Identity: 208/489 - (42%)
• Similarity: 297/489 - (60%)
• Gaps: 39/489 - (7%)

  Fly    23 DEKDKAIIVKMNKSSSNNNDSKETTPLNVDQL-VAASNPAVAGEQSAVCLEDTYKRTSTYASNIN 86
            ||::...:.:.:..:|:::.:..:...|...| :..||...:||:...  ||..........:..
Zfish    19 DEEEVMRLAQSDDGTSSHSGTLPSPNCNGKVLSILHSNGGRSGERDED--EDDDDDADKDDDDEE 81

  Fly    87 STGGE--SSGSGTQLSRKESILGSFHRQIRRSIKAVSESPGPLTRYRQTRFSSRRVRKRVVFKHG 149
            ..||.  ..|.|:.||.:..:.|.:.|..|.|:.::  ||.||   |..|..|||.|:|.|.|.|
Zfish    82 EGGGRRGGGGRGSALSGESGVEGRWERNKRASLPSL--SPTPL---RDRRRQSRRPRRRFVGKDG 141

  Fly   150 ECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTN 214
            .|||...|:::|.:|||.|:|||.||.:|||.|:||..||:.:|..|||.:|:||.||.||....
Zfish   142 RCNVTFVNMSERGQRYLTDLFTTCVDIRWRWMLVVFTLSFLLTWLLFGFTFWLIAAAHGDLNPLA 206

  Fly   215 LKNQSP-------------------DLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVT 260
            ..:.||                   ::||. |...|..||::.|:|||:|:||||:||||.|.||
Zfish   207 SSSSSPSSLSSSLAPLDATEGSSRVEMVAE-TEEPCFQQVNSFMAAFLFSLETQTSIGYGFRSVT 270

  Fly   261 EECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGD 325
            |.||.|:..:.:|||.|..|.||::|.|.||:::||||.:||:||..||:..|||..|:|:|||:
Zfish   271 EACPLAVLAVVLQCIVGCIIDAFIIGAVMAKIAKPKKRNETLVFSDVAVVAVRDGKLCMMWRVGN 335

  Fly   326 MRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYM 390
            :||||::|||||||:::.:||.|||.||....:|::|.|.|.||:..:.|.||||:|:..||.:.
Zfish   336 LRKSHLVEAHVRAQLLKPRVTPEGEFLPLDNSDLNVGFDTGTDRIFLVSPVTIVHEINEESPFFE 400

  Fly   391 LSASDMLKER-FEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTL 454
            :....:..:: .||||:|||::|:|.||||.|||:|.||:||||||..|:..||..  |:|||:.
Zfish   401 MDKGALEGDKDLEVVVILEGMVEATAMTTQCRSSFLASEILWGHRFEPVLFERKNC--YQVDYSY 463

  Fly   455 FNNTYDV-DTPLCSAKQLDELKSEY---SKSAKC 484
            ||.||:| |||.||||:|.|.|  |   |:|:.|
Zfish   464 FNRTYEVTDTPTCSAKELAEKK--YIAGSRSSFC 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	75/168 (45%)
		IRK_C	302..476	CDD:465439	91/175 (52%)
kcnj14	XP_073780606.1	None