Protein Alignment Irk1 and kcnj14

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_002935044.1
• Gene: kcnj14 / 100498359
• XenbaseID: XB-GENE-490027
• Length: 433
• Species: Xenopus tropicalis
• Alignment Length: 392
• Identity: 186/392 - (47%)
• Similarity: 256/392 - (65%)
• Gaps: 28/392 - (7%)

  Fly   113 IRRSIKAVS-ESPGPL--------------TRYRQTRFSSR--RVRKRVVFKHGECNVVQGNVAK 160
            :.|:|:..| :.|.||              |.||..:..::  |.|.|.|.|.|.|||...|:::
 Frog     3 VARAIRRFSTDIPDPLREEEESQLTQAMRPTPYRNGKVHTKPTRQRSRFVQKDGHCNVEFINLSE 67

  Fly   161 RRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVAN 225
            :.:|||.|:|||.||.:|||..|:|:.:||.||..|||.:|:||..|.||.      ..|:..:.
 Frog    68 KSQRYLTDLFTTCVDIRWRWMFLIFSFTFVVSWLIFGFTFWLIASLHGDLA------PPPEPGSE 126

  Fly   226 ITHTV-CVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVF 289
            ..|.. |..||::.|:|||:|:||||:||||.|.||||||.|:.|:.:|||.|..|.||::|.:.
 Frog   127 EAHNAPCFLQVTSFMAAFLFSLETQTSIGYGFRSVTEECPMAVLTVVLQCIVGCIIDAFIIGAIM 191

  Fly   290 AKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPF 354
            ||:::||||.:||:|:.||||..||...|||:||.::||||::|||||||:::.:||.|||.||.
 Frog   192 AKIAKPKKRNETLVFTENAVIALRDEKLCLMWRVANLRKSHLVEAHVRAQLLQPRVTPEGEYLPL 256

  Fly   355 YQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQ 419
            ...::::|.|.|.||:..:.|.||||:||..||||.:...::....||:||:|||::|:|.||||
 Frog   257 DHTDINVGFDSGTDRIFLVSPVTIVHEIDEESPLYEIGKEELEAANFELVVILEGMVEATAMTTQ 321

  Fly   420 ARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDV-DTPLCSAKQLDELK-SEYSKSA 482
            .||||||||:|||.||..|: |.|. ..|||||..||:||:| .||.||||:|.|.| |...:|:
 Frog   322 CRSSYLPSEILWGSRFEPVL-FEKR-NYYEVDYLHFNSTYEVPSTPTCSAKELSERKYSLVGRSS 384

  Fly   483 KC 484
            .|
 Frog   385 FC 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	71/150 (47%)
		IRK_C	302..476	CDD:465439	95/175 (54%)
kcnj14	XP_002935044.1	IRK	52..197	CDD:460023	71/150 (47%)
		IRK_C	204..377	CDD:465439	94/174 (54%)