Protein Alignment Irk1 and kcnj2

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_004916397.1
• Gene: kcnj2 / 100497641
• XenbaseID: XB-GENE-1012188
• Length: 425
• Species: Xenopus tropicalis
• Alignment Length: 381
• Identity: 183/381 - (48%)
• Similarity: 258/381 - (67%)
• Gaps: 18/381 - (4%)

  Fly    96 GTQLSRKESILGSFHRQIRRSIKAVSESPGPLTRYRQTRFSSRRVRKRVVFKHGECNVVQGNVAK 160
            |:..:.:.|::.|....::.:..||:...|.......||   ::.|.|.|.|.|.|||...||::
 Frog     2 GSVRTNRYSVVSSEEDGMKLATMAVANGYGNGKSKIHTR---QQCRSRFVKKDGHCNVQFINVSE 63

  Fly   161 RRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWIIAYAHNDLEYTNLKNQSPDLVAN 225
            :.:|||.|||||.||.:|||.|::|..:|:.||.|||.::|:||..|.||       .:|:
 Frog    64 KGQRYLSDIFTTCVDIRWRWMLVIFCLAFILSWLFFGCVFWLIALLHEDL-------GAPE---- 117

  Fly   226 ITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAIFTMCIQCITGVFIQAFMVGIVFA 290
             :|..||||||:..:|||:|:|||||||||.|.||:|||.|:|.:..|.|.|..|.||::|.|.|
 Frog   118 -SHKPCVTQVSSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMA 181

  Fly   291 KLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFY 355
            |:::||||.:||:||.||||..|||..|||:|||::||||::|||||||:::.::|.|||.:|..
 Frog   182 KMAKPKKRNETLVFSDNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLD 246

  Fly   356 QQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDMLKERFEVVVMLEGVIESTGMTTQA 420
            |.::::|.|.|.||:..:.|.||||:|:..||||.||..|:....||:||:|||::|:|.||||.
 Frog   247 QIDINVGFDSGIDRIFLVSPITIVHEINEESPLYDLSKQDLDNSDFEIVVILEGMVEATAMTTQC 311

  Fly   421 RSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDV-DTPLCSAKQLDELK 475
            |||||.||:|||||:..|:.  :|...|:|||:.|:.||:| :||||.|:.|.|.|
 Frog   312 RSSYLASEILWGHRYEPVLF--EERNYYKVDYSRFHKTYEVPNTPLCCARDLAEKK 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	74/149 (50%)
		IRK_C	302..476	CDD:465439	94/175 (54%)
kcnj2	XP_004916397.1	IRK_N	1..47	CDD:462486	9/47 (19%)
		IRK	48..186	CDD:460023	74/149 (50%)
		IRK_C	193..366	CDD:465439	94/175 (54%)