Protein Alignment Irk1 and kcnj20

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_017951170.2
• Gene: kcnj20 / 100492899
• XenbaseID: XB-GENE-25875140
• Length: 603
• Species: Xenopus tropicalis
• Alignment Length: 488
• Identity: 171/488 - (35%)
• Similarity: 273/488 - (55%)
• Gaps: 57/488 - (11%)

  Fly    37 SSNNNDSKETTPLNVDQLVAASNPAVAGEQSAVCL--ED--TYKRTSTYASNINSTGGESSGSGT 97
            :::..:|::.....||:..:.:...:...:.:|.:  ||  .|:|.....:.|...|.:
 Frog   111 ANSTKESRQRRSSTVDRTSSTAATQLVKHRPSVTINTEDLPRYQRAGKQETPIQEVGNK------ 169

  Fly    98 QLSRKESILGSFHRQIRRSIKAV---SESP------GPLTRY------------RQT-RFSSRRV 140
                       :|.:...|:..:   |::|      .|:|..            ||. ..::|:.
 Frog   170 -----------WHPKHALSVPNIPMRSKTPTRSVVSAPVTTKSHRMRCKLMYDDRQLFNLTNRQT 223

  Fly   141 RKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWIIAY 205
            |:|.|.|.|:|.|..|.: :.:.|:|.|||||:||.::||.:.||...::.:|..|..|:::.|.
 Frog   224 RQRYVTKDGKCRVNLGRI-EEKSRFLSDIFTTIVDLKYRWFIFVFMLCYIVTWVAFAVIYFVDAL 287

  Fly   206 AHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAIFTM 270
            ..:|:.:.......|          |:..|.|.:||.|:|||||.|||||.|.|:.:|||.:..:
 Frog   288 LRDDVNHIGDPKWKP----------CIDNVDNFLSALLFSVETQRTIGYGTRMVSADCPEGVILI 342

  Fly   271 CIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHIIEAH 335
            ..|.|.|..|.|.|||.:|.|:|||||||:||:||:..|:.|||...|||||:||:|.||:::|.
 Frog   343 MAQSILGSMIDALMVGCMFVKISRPKKRAETLIFSKKCVVSHRDEKLCLMFRIGDLRDSHMVDAK 407

  Fly   336 VRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDMLKER 400
            :||::|:.:.|||||.:|..|.|:::|.|.|||||..:.|..|.|.|:.:||.:.::|..:.:|.
 Frog   408 IRAKLIKSRQTKEGEFIPLEQSEINLGYDTGEDRLFLVEPQIICHFINDHSPFWEMTAESLKREE 472

  Fly   401 FEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDVDTPL 465
            ||::|:|||::|:||||.||::||...|:||||||...::..|  |.:.|||:.|:.|:||.||.
 Frog   473 FEIIVILEGIVEATGMTCQAKTSYTEDEILWGHRFEPCMTLEK--GAFRVDYSHFDKTFDVQTPW 535

  Fly   466 CSAKQLDELKSEYSKSAKCVNAPFADRTLSASL 498
            .|||::.|.| |..::.:...:.:.|..|...|
 Frog   536 SSAKEMHEQK-EMEQNDRSTLSLYWDNMLQTCL 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	57/149 (38%)
		IRK_C	302..476	CDD:465439	81/173 (47%)
kcnj20	XP_017951170.2	IRK	228..367	CDD:460023	57/149 (38%)
		IRK_C	374..546	CDD:465439	82/174 (47%)