Protein Alignment Irk1 and kcnj4

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_002934259.1
• Gene: kcnj4 / 100485222
• XenbaseID: XB-GENE-493748
• Length: 442
• Species: Xenopus tropicalis
• Alignment Length: 355
• Identity: 184/355 - (51%)
• Similarity: 245/355 - (69%)
• Gaps: 14/355 - (3%)

  Fly   136 SSRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIW 200
            |.|:.|.|.|.|:|:|||...|::.:.:||:.|||||.||.:||:.||:|:|:|:.||.||.|::
 Frog    39 SRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLLIFSATFLASWLFFAFLF 103

  Fly   201 WIIAYAHNDLEYTNLKNQSPDLVANITH---TVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEE 262
            |.||:.|.||      ..|..::|....   ..|:..|::.:.|||:|||||||||||.|.||:|
 Frog   104 WCIAFLHGDL------GTSSGVIAGGRQGPPKPCLMHVNSFVEAFLFSVETQTTIGYGFRCVTDE 162

  Fly   263 CPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMR 327
            ||.||..:..|.|.|..|.:||:|.:.||::||||||||||||.:|||..|||..|||:|||::|
 Frog   163 CPLAILAVVAQSILGCLIDSFMIGTIMAKMARPKKRAQTLLFSHHAVIALRDGKLCLMWRVGNLR 227

  Fly   328 KSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLS 392
            ||||:|||||||:||..||:|||.||..|::|::|.|.|.||:..:.|..|||:||..||||.:.
 Frog   228 KSHIVEAHVRAQLIRPYVTQEGEYLPVDQRDLNVGYDSGLDRIFLVSPIIIVHEIDEESPLYTMG 292

  Fly   393 ASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNN 457
            ...:..|.||:||:|||::|:|.||||||||||.||:.|||||..||.  :|...|:|||:.|:.
 Frog   293 KEQLEGEDFEIVVILEGMVEATAMTTQARSSYLASEIRWGHRFEPVVF--EEKNHYKVDYSHFHK 355

  Fly   458 TYDV-DTPLCSAKQLDELKSEY--SKSAKC 484
            ||.| .||:|||::|.|.:...  |.||.|
 Frog   356 TYQVPGTPVCSARELHESRITVLPSPSAFC 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	69/152 (45%)
		IRK_C	302..476	CDD:465439	99/174 (57%)
kcnj4	XP_002934259.1	IRK_N	1..47	CDD:462486	3/7 (43%)
		IRK	48..195	CDD:460023	69/152 (45%)
		IRK_C	202..372	CDD:465439	98/171 (57%)