Protein Alignment Irk1 and kcnj3a

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_002663356.3
• Gene: kcnj3a / 100330491
• ZFINID: ZDB-GENE-100922-16
• Length: 490
• Species: Danio rerio
• Alignment Length: 477
• Identity: 192/477 - (40%)
• Similarity: 278/477 - (58%)
• Gaps: 37/477 - (7%)

  Fly   138 RRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSWAFFGFIWWI 202
            ||.|:|.|.|:|.|||..||:.....|||.|:||||||.:|||.|.:|..::..:|.|..|:||:
Zfish    27 RRKRQRFVDKNGRCNVQHGNLGGETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMAFMWWV 91

  Fly   203 IAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRYVTEECPEAI 267
            |||...||..|:.:..:|          ||..|.|..||||:.:||:.|||||:||:|::|||.|
Zfish    92 IAYIRGDLNRTHDEKYTP----------CVANVYNFPSAFLFFIETEATIGYGHRYITDKCPEGI 146

  Fly   268 FTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRVGDMRKSHII 332
            .....|.|.|..:.||::|.:|.|:|:|||||:||:||.||.|..|||...||||||::|.||::
Zfish   147 ILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSENAAISMRDGKLTLMFRVGNLRNSHMV 211

  Fly   333 EAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPLYMLSASDML 397
            .|.:|.::::.:.|.|||.||..|.||.:|...|.|:|..:.|.||.|.||..||.|.||...|.
Zfish   212 SAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDTKSPFYELSQHSMQ 276

  Fly   398 KERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYTLFNNTYDVD 462
            .|:||:||:|||::|:||||.|||:||...||||||||..|:|.  |.|.::|||:.|:.|::|.
Zfish   277 TEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISL--EEGFFKVDYSQFHATFEVP 339

  Fly   463 TPLCSAKQLDELKSEYSKSAKCVNAPFADRTLSASLFQRIASAASVDHL----DPASDESLDSGR 523
            ||..|||:.||        |..:::|.    ::.||.......:|:|.|    ||.|...|.:
Zfish   340 TPPYSAKEQDE--------ALLMSSPL----MAPSLCNSGEKNSSLDCLELLEDPESTTKLPA-- 390

  Fly   524 LQIRSHSIPNGVLASELEPLNNNKHGASFTMGGLTI----TTTAPSIPNLSSINEKTN-SGNSIN 583
             :::..:..:| |..:|..:::.....::::|.|.|    .::.|.:.....:.:.|. |..:|:
Zfish   391 -KVQKMTGRDG-LPRKLLRMSSTTSEMTYSLGELPIKLQRISSVPGVLEEMQVTKTTRISSEAIS 453

  Fly   584 SSNYSNNNSLSTLTGGGSAASG 605
            .|.......|..|:|||....|
Zfish   454 KSVADLPPKLQRLSGGGGRMDG 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	66/149 (44%)
		IRK_C	302..476	CDD:465439	88/173 (51%)
kcnj3a	XP_002663356.3	None