Protein Alignment Irk1 and kcnj19b

DIOPT Version :10

• Sequence 1: NP_001262861.1
• Gene: Irk1 / 42742
• FlyBaseID: FBgn0265042
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_001340328.2
• Gene: kcnj19b / 100000044
• ZFINID: ZDB-GENE-121214-60
• Length: 505
• Species: Danio rerio
• Alignment Length: 511
• Identity: 196/511 - (38%)
• Similarity: 281/511 - (54%)
• Gaps: 64/511 - (12%)

  Fly   131 RQTRFS--SRRVRKRVVFKHGECNVVQGNVAKRRRRYLQDIFTTLVDAQWRWTLLVFAASFVFSW 193
            |...||  ::|.|:|.|.|:|.|||..||:.....||:.|:||||||.:|||.||:|..::..:|
Zfish    19 RAMSFSAPAKRKRQRFVEKNGRCNVQHGNLGGETSRYISDLFTTLVDLKWRWNLLIFLLTYTVAW 83

  Fly   194 AFFGFIWWIIAYAHNDLEYTNLKNQSPDLVANITHTVCVTQVSNMMSAFLYSVETQTTIGYGNRY 258
            .....:||||||...||.:.:          :.::|.||..|.|..||||:.:||:.|||||.||
Zfish    84 LIMASMWWIIAYIRGDLGHGH----------DDSYTPCVANVYNFPSAFLFFIETEATIGYGYRY 138

  Fly   259 VTEECPEAIFTMCIQCITGVFIQAFMVGIVFAKLSRPKKRAQTLLFSRNAVICHRDGVPCLMFRV 323
            :||:|||.|.....|.:.|..:.||::|.:|.|:|:|||||:||:||::|||..|||..||||||
Zfish   139 ITEKCPEGIILFLFQSLLGSIVDAFLIGCMFIKMSQPKKRAETLMFSQDAVISQRDGKLCLMFRV 203

  Fly   324 GDMRKSHIIEAHVRAQIIRKKVTKEGEVLPFYQQELHIGADGGEDRLMFIWPTTIVHKIDRNSPL 388
            |::|.||::.|.:|.::|:.:.|.|||.||..|:||.:|...|.|:|..:.|.||.|:|:.|||.
Zfish   204 GNLRNSHMVSAQIRCKLIKSRQTPEGEFLPLDQRELDVGFGTGADQLFLVSPLTICHEINSNSPF 268

  Fly   389 YMLSASDMLKERFEVVVMLEGVIESTGMTTQARSSYLPSEVLWGHRFVNVVSFRKETGEYEVDYT 453
            :.||...::.|:||:||:|||::|:||||.|||:||...||||||||:.|:|.  |.|.:.|||:
Zfish   269 FDLSQRSLMNEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFLPVMSL--EEGFFRVDYS 331

  Fly   454 LFNNTYDVDTPLCSAKQLDELKSEYSKSAKCVNAPFADRTLSASLF-----QRIASAASVDHLDP 513
            .|:||::|.||..|.|:.||..|          .|.....||.:|.     :||.|...|.|
Zfish   332 QFHNTFEVPTPPYSVKEQDEKSS----------LPSPGPVLSPTLIEGRRRERIFSLDGVPH--- 383

  Fly   514 ASDESLDSGRLQIRSHSIPNGVLASELEPLNNNKHGASFTMGGLTITTTAPS--------IPNLS 570
             |||              |...|.|:|:.: .:|:|......|....|...|        :..|.
Zfish   384 -SDE--------------PGSKLPSKLQRM-CSKNGKEVLKTGSPQPTEKASSTGDLPLRVQRLG 432

  Fly   571 SINEKTNSGNSINSSNYSNNNSLSTLTGG--------GSAASGPGGGITIVAGSGN 618
            |:.....:.|.:........:...|.:.|        .:.|..||..:.::.||.:
Zfish   433 SLVGHGETENHLRLKPLKMGSETHTQSAGELEHRRKLSAPAPVPGPSLNLLPGSSS 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk1	NP_001262861.1	IRK	145..295	CDD:460023	64/149 (43%)
		IRK_C	302..476	CDD:465439	88/173 (51%)
kcnj19b	XP_001340328.2	IRK	35..175	CDD:460023	64/149 (43%)
		IRK_C	182..352	CDD:465439	87/171 (51%)