DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unk and unk

DIOPT Version :9

Sequence 1:	NP_001303430.1	Gene:	unk / 42738	FlyBaseID:	FBgn0004395	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_956530.2	Gene:	unk / 393205	ZFINID:	ZDB-GENE-040426-707	Length:	777	Species:	Danio rerio

Alignment Length:	760	Identity:	294/760 - (38%)
Similarity:	407/760 - (53%)	Gaps:	138/760 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLSSQQEKPNHYTYLKEFRVEQCQSFLQHKCNQHRPFVCFNWHFQNQRRRRPVRKRDGTFNYSAD 74
            :|.:|.|||.|||||||||.|||..|:||||.|||||.||:|||.|||||||:|:||||||||.|
Zfish    39 VLHAQPEKPQHYTYLKEFRTEQCPLFVQHKCTQHRPFTCFHWHFLNQRRRRPIRRRDGTFNYSPD 103

  Fly    75 NYCTKYDETTGICPEGDECPYLHRTAGDTERRYHLRYYKTCMCVHDTDSRGYCVKNGLHCAFAHG 139
            .||.||||.||.||:|||||:|||||||||||||||||||..|:|:||.:|:|.|||.|||||||
Zfish   104 VYCVKYDEGTGTCPDGDECPFLHRTAGDTERRYHLRYYKTGSCIHETDGKGHCSKNGPHCAFAHG 168

  Fly   140 MQDQRPPVYDIKELETLQNAESTLDSTN-----------ALNALDKERNLMNEDPKWQDTNYVLA 193
            ..|.|.|||||:|::.|: |::|...|.           |..||.::  :::|||:|||.::||:
Zfish   169 SHDLRSPVYDIREVQVLE-AQATTGLTEGSSGEGQSGVVASTALIEK--ILSEDPRWQDNSFVLS 230

  Fly   194 NYKTEPCKRPPRLCRQGYACPQYHNSKDKRRSPRKYKYRSTPCPNVKHGEEWGEPGNCEAGDNCQ 258
            :||||.||:||||||||||||.||||||:||||.|:|||:.|||:|||.:|||:|..||.|:.||
Zfish   231 HYKTELCKKPPRLCRQGYACPYYHNSKDRRRSPHKHKYRALPCPSVKHSDEWGDPSKCEGGEGCQ 295

  Fly   259 YCHTRTEQQFHPEIYKSTKCNDVQQAGYCPRSVFCAFAHVEPCSIDEKTRDHTVYLNELISNAYP 323
            ||||||||||||||||||||||:||:|.|||..||||||:|..|:.:             ..:.|
Zfish   296 YCHTRTEQQFHPEIYKSTKCNDIQQSGNCPRGPFCAFAHLEKVSVGD-------------GCSSP 347

  Fly   324 DLKAQDAFQRVDNLLNIDGNST-------------NKMLVDALENTT-NFSKFLSFSRPLDSRSA 374
            .|.|  ||:...:    .|.||             :...:||..... .:.|...|.|...::..
Zfish   348 PLSA--AFEDFSH----SGPSTLTEEGMLGRGLFDDSCSLDASPGAEGGYGKAPGFEREDQAKHK 406

  Fly   375 CSMDDPRENSLSASLANTSLLTRSSAPINIPNTTLSNSINDFNSGSFAVNIPS------------ 427
            |...:.|...:|:..:...||.  ..|:..| .::|:|:    ..|.|...||
Zfish   407 CFSMEQRSRDVSSMHSKQDLLV--FLPVGSP-LSMSSSV----PSSLAATPPSPAPPGPSSGMNA 464

  Fly   428 SSLTYSPTN-------HANLFNVDAFNYGGSNKLSNSL--------------SATQNDSSLFFPS 471
            ::|.:.||:       .:.|.::|..::|.| .|..||              |..|:.:.:..|.
Zfish   465 NALPFYPTSDTVESVVESALDDLDLNDFGVS-ALEKSLESSALPSMGLMLGGSQLQSSAPVNIPG 528

  Fly   472 RIISPGFGDGLSISPSVRI------------------SELNTIRDDINSSSVGNSLFENTLNTAK 518
            .:.||......|.||.:|.                  |.|.|....:..:.:.:|::|:......
Zfish   529 SLSSPSPFRSPSPSPPIRAHHSPFLSAQLPQPSQSESSFLGTSHGSLGLNGMSSSIWEHFPTGQS 593

  Fly   519 NAFSLQSLQSQNN--SDLGRITNELLTKNAQIHKLNGRFEDMACKLKIAE--------------L 567
            :..:..:|.|..:  |:..|:..|:...:..:...:..:..||..|.:.:              :
Zfish   594 SPGTPPALLSAGSMYSETSRLKQEVEEAHRVLKHWDHSWRQMAQSLAVLKADAEDARLLAGQLGM 658

  Fly   568 HRDKAKQ-------------EAQEWKERYDLAQIQLNLPAELRDLSIQKLKQLQSKLRTDLEEVD 619
            ..::|:|             ||.|.....:...:||:....|..|.:..:..||:::.:.|..|:
Zfish   659 EAERARQAEVEAQQQAALLEEALETLRHAENPHLQLHQLQLLHRLPLSSICSLQAQICSCLRTVE 723

  Fly   620 KVLYLENAKKCMKCEENNRTVTLEPCNHLSICNTCAESVTECPYC 664
            :.::.:....|:.|:|.. :||| ||.|...|..||.| ||||.|
Zfish   724 QAVFRKQRLYCVSCDELG-SVTL-PCQHGLHCERCATS-TECPLC 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unk	NP_001303430.1	zf-CCCH	273..299	CDD:279036	20/25 (80%)
		FhaB	<311..548	CDD:225751	55/303 (18%)
		zf-C3HC4_3	626..671	CDD:290631	18/39 (46%)
unk	NP_956530.2	FinO_conjug_rep	577..671	CDD:301594	20/120 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575837
Domainoid	1	1.000	358	1.000	Domainoid score	I926
eggNOG	1	0.900	-	-		E1_KOG1100
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	523	1.000	Inparanoid score	I1215
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D316647at33208
OrthoFinder	1	1.000	-	-		FOG0003517
OrthoInspector	1	1.000	-	-		otm26297
orthoMCL	1	0.900	-	-		OOG6_105234
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7783
SonicParanoid	1	1.000	-	-		X1211
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.690