DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unk and Unkl

DIOPT Version :9

Sequence 1:	NP_001303430.1	Gene:	unk / 42738	FlyBaseID:	FBgn0004395	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	XP_006246119.1	Gene:	Unkl / 302987	RGDID:	1565247	Length:	727	Species:	Rattus norvegicus

Alignment Length:	763	Identity:	319/763 - (41%)
Similarity:	426/763 - (55%)	Gaps:	170/763 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QQEKPNHYTYLKEFRVEQCQSFLQHKCNQHRPFVCFNWHFQNQRRRRPVRKRDGTFNYSADNYCT 78
            |.|||.||.||||||.|||..||||||:|||||.||:|||.|||||||:|:||||||||.|.||:
  Rat    18 QTEKPTHYRYLKEFRTEQCSLFLQHKCSQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCS 82

  Fly    79 KYDETTGICPEGDECPYLHRTAGDTERRYHLRYYKTCMCVHDTDSRGYCVKNGLHCAFAHGMQDQ 143
            ||||.||:||:||||||||||.|||||:||||||||..|:|:||:||:|||||||||||||..|.
  Rat    83 KYDEATGLCPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDL 147

  Fly   144 RPPVYDIKEL---ETLQNAE-STLDSTNALN--------ALDKERNLMNEDPKWQDTNYVLANYK 196
            ||||.||:||   |.|||.: |..|....|.        .::|   ::.|||:|||:|:||.:||
  Rat   148 RPPVCDIRELQAQEALQNGQLSGGDGVPDLQPGVLASQAMIEK---ILGEDPRWQDSNFVLGSYK 209

  Fly   197 TEPCKRPPRLCRQGYACPQYHNSKDKRRSPRKYKYRSTPCPNVKHGEEWGEPGNCEAGDNCQYCH 261
            ||.|.:||||||||||||.||||:|:||:||:::|||||||:||||:|||||..|:.||:|||||
  Rat   210 TEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDVGDSCQYCH 274

  Fly   262 TRTEQQFHPEIYKSTKCNDVQQAGYCPRSVFCAFAHVEPC--SIDE-KTRDHTVYLNELISNAYP 323
            :||||||||||||||||||::|.|||||..||||||:|..  .::| ..||       |.||:..
  Rat   275 SRTEQQFHPEIYKSTKCNDMRQTGYCPRGPFCAFAHIEKSLGMVNEWSCRD-------LSSNSTS 332

  Fly   324 DLKAQ-DAFQRVDNLLNIDGNSTNKMLVDALENTTNFSKFLSFSRPLDSRSACSMDDPRENSLSA 387
            ...:| .:.:|.|:    ....:.|...|:.:|  :.:.|             |:..|...|:|:
  Rat   333 AYSSQPGSAKRKDS----PSEGSQKATEDSKQN--HLAVF-------------SVVHPLAPSISS 378

  Fly   388 SLAN---TSLLTRSSAPINIPN--------------------TTLSNSINDFN------------ 417
            |:|:   :|..:.||:|..:||                    :.|...::|.|
  Rat   379 SVASSLASSTGSGSSSPTTLPNLPARALPLDPAGNTVEAVIGSALDLRLSDINIASLDKDLEEQD 443

  Fly   418 ---------SGSFAVNIPSSSLTYSPTNHANLFNVDAFNYGGSNKLSNSLSATQNDSSLFFPSRI 473
                     :||..|.|| .||..||:.|::    .:.:....:.||.|||.....|::..|.:
  Rat   444 LGLTGPRSLAGSAPVTIP-GSLPRSPSLHSS----SSLSTSPLSSLSQSLSGPLVSSAMTPPQQ- 502

  Fly   474 ISPGFGDGLSISPSVRISELNTIRDDINS-SSVG-----NSLFE-----------NTLNTAKNAF 521
                       .|.:| ||..|:....:| ||:|     .|:::           ..||:..:|
  Rat   503 -----------PPPLR-SEPATLGSTASSYSSLGLNGVPGSIWDFVSGSFSPSPSPILNSGPSA- 554

  Fly   522 SLQSLQSQNNSDLGRITNELLTKNAQIHKLNGRFEDM--ACKLKIAELHRDKAKQEAQEWKERYD 584
              .|..|.|:::|.|:..:|.....:|.:....::.:  ||         |..::||||.|||..
  Rat   555 --SSSASPNSAELARVRRQLDEAKRKIRQWEESWQQVKQAC---------DAWQREAQEAKERAR 608

  Fly   585 LA-------------------QIQ--------LNLP-----AELRDLSIQKLKQLQSKLRTDLEE 617
            :|                   |:|        .:||     .::.|:.:.||..|||:||.|||.
  Rat   609 VADSDRQLALQRKEEVEAQVKQLQEELEGLGLSSLPGLRSLGDISDIPLPKLHSLQSQLRLDLEA 673

  Fly   618 VDKVLYLENAKKCMKCEENNRTVTLEPCNHLSICNTCAESVTECPYCQ 665
            ||.|::...||:|:.|:|......|.||.|..:|..||.|..|||||:
  Rat   674 VDGVIFQLRAKQCVACQERAHGTVLRPCQHRVLCEPCAASTPECPYCK 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unk	NP_001303430.1	zf-CCCH	273..299	CDD:279036	20/25 (80%)
		FhaB	<311..548	CDD:225751	61/298 (20%)
		zf-C3HC4_3	626..671	CDD:290631	18/40 (45%)
Unkl	XP_006246119.1	zf-CCCH	286..310	CDD:279036	18/23 (78%)
		DUF4200	564..>638	CDD:290574	17/82 (21%)
		zf-C3HC4_3	684..721	CDD:290631	16/36 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336697
Domainoid	1	1.000	358	1.000	Domainoid score	I939
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	584	1.000	Inparanoid score	I971
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D316647at33208
OrthoFinder	1	1.000	-	-		FOG0003517
OrthoInspector	1	1.000	-	-		otm44853
orthoMCL	1	0.900	-	-		OOG6_105234
Panther	1	1.100	-	-	LDO	PTHR14493
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1211
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.900