Protein Alignment hh and Dhh

DIOPT Version :10

• Sequence 1: NP_001034065.1
• Gene: hh / 42737
• FlyBaseID: FBgn0004644
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_445819.1
• Gene: Dhh / 84380
• RGDID: 620711
• Length: 396
• Species: Rattus norvegicus
• Alignment Length: 408
• Identity: 200/408 - (49%)
• Similarity: 260/408 - (63%)
• Gaps: 26/408 - (6%)

  Fly    64 LTSLVALLLIVLPMVFSPAHSCGPGRG-LGRHR--ARNLYPLVLKQTIPNLSEYTNSASGPLEGV 125
            |..|..|.|:.|.:     .||||||| :||.|  .:.|.||:.||.:|::.|.|..||||.||.
  Rat     7 LLPLCCLALLALSV-----QSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSMPERTLGASGPAEGR 66

  Fly   126 IRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDE 190
            :.|.|.:|:|||||||.||:|:|||.:||||||::||||::|.||.:|||.|||:||.|||.|||
  Rat    67 VTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDE 131

  Fly   191 DYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHV 255
            |.||.|:||||||||:.|.|||||::|||:|||||||||||||.|.||.||:.|||:|:|::...
  Rat   132 DGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVSVKADNSLAVRA 196

  Fly   256 HGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTD-G 319
            .|||...:|..|.||.||.|.||..||.||:..|.|:.|.:.|:||:||:|::..:||.:.|: .
  Rat   197 GGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERP 261

  Fly   320 GAVLTVTPAHLVSVWQ---PESQKLTFVFADRIEEKNQVLVRDVETGELRPQRVVKVGSVRSKGV 381
            ...|.:||.|||...:   |.......|||.|:...:.||....:.  |||.||.:|....:.||
  Rat   262 PRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDA--LRPARVARVAREEAVGV 324

  Fly   382 VAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWLPAKEQLHSSPKVVSSAQQQ 446
            .||||..||::||.|.||||||:.|...||...||:|||..|.|.||            ..|.|.
  Rat   325 FAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLP------------GGAVQP 377

  Fly   447 NGIHWYANALYKVKDYVL 464
            .|:|||:..||::.:.::
  Rat   378 TGMHWYSRLLYRLAEELM 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	85..243	CDD:460055	105/160 (66%)
		Hint	254..465	CDD:460051	84/215 (39%)
Dhh	NP_445819.1	HH_signal	23..185	CDD:460055	105/161 (65%)
		Hint	187..394	CDD:460051	87/220 (40%)