DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hh and SHH

DIOPT Version :9

Sequence 1:	NP_001034065.1	Gene:	hh / 42737	FlyBaseID:	FBgn0004644	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_000184.1	Gene:	SHH / 6469	HGNCID:	10848	Length:	462	Species:	Homo sapiens

Alignment Length:	456	Identity:	202/456 - (44%)
Similarity:	267/456 - (58%)	Gaps:	52/456 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RCLSRLTSLVALLLIVLPMVFSPAHSCGPGRGLGRHR-ARNLYPLVLKQTIPNLSEYTNSASGPL 122
            |||        ||::|..::.....:||||||.|:.| .:.|.||..||.|||::|.|..|||..
Human     6 RCL--------LLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRY 62

  Fly   123 EGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTES 187
            ||.|.|:|.:||:|.||||.||:|:|||.|||||||::|||:|||.||.||||:|||::|.|||.
Human    63 EGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEG 127

  Fly   188 WDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSIS 252
            ||||.||.:||||||||||.|.|||||:||||||||||||||||||.|.|:.||:||||:::|::
Human   128 WDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVA 192

  Fly   253 SHVHGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHT 317
            :...|||...:|..||.|..|.:.:||.|||||:....|:.:||:.:.|:||:....:.|..:.|
Human   193 AKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIET 257

  Fly   318 -DGGAVLTVTPAHLVSV--------WQPESQKLT-----------FVFADRIEEKNQVLVRDVET 362
             :....|.:|.|||:.|        .:||:...:           .:||.|:....:|.|.....
Human   258 REPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALGPRALFASRVRPGQRVYVVAERD 322

  Fly   363 GELR--PQRVVKVG-SVRSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLE 424
            |:.|  |..|..|. |..:.|..||||.:|||::|.|.|||||||...|.||...||.||...|.
Human   323 GDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALL 387

  Fly   425 AWL-PAKEQ-----------------LHSSPKVVSS--AQQQNGIHWYANALYKVKDYVLPQSWR 469
            |.| ||:..                 ..::|....:  |....|||||:..||::..::|.....
Human   388 AALAPARTDRGGDSGGGDRGGGGGRVALTAPGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEAL 452

  Fly   470 H 470
            |
Human   453 H 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432	101/143 (71%)
		Hint	254..465	CDD:279426	80/253 (32%)
		Hint	258..400	CDD:238035	52/164 (32%)
SHH	NP_000184.1	Cardin-Weintraub. /evidence=ECO:0000269\|PubMed:23118222	32..38		1/5 (20%)
		HH_signal	39..184	CDD:279432	101/144 (70%)
		Hint	187..448	CDD:279426	81/260 (31%)
		Hint	198..363	CDD:238035	52/164 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..302		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..414		0/18 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2389
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30961
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2177
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S4101
OMA	1	1.010	-	-		QHG50028
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	1	1.000	-	-		FOG0001612
OrthoInspector	1	1.000	-	-		otm41846
orthoMCL	1	0.900	-	-		OOG6_104977
Panther	1	1.100	-	-	O	PTHR11889
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790