Protein Alignment hh and dhh

DIOPT Version :10

• Sequence 1: NP_001034065.1
• Gene: hh / 42737
• FlyBaseID: FBgn0004644
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_001025286.2
• Gene: dhh / 558147
• ZFINID: ZDB-GENE-990714-5
• Length: 447
• Species: Danio rerio
• Alignment Length: 449
• Identity: 183/449 - (40%)
• Similarity: 248/449 - (55%)
• Gaps: 56/449 - (12%)

  Fly    61 LSRLTSLVALL---LIVLPMVFSPAHSCGPGRGL-GRHRARNLYPLVLKQTIPNLSEYTNSASGP 121
            |:||..|.|.|   |:|        ..||||.|. ||||.|.|.|:..||.:|.:||....|||.
Zfish     9 LARLGLLTACLYSWLVV--------DGCGPGPGYGGRHRQRKLTPMSYKQYVPGVSENNLGASGR 65

  Fly   122 LEGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTE 186
            .||.|.|.|.:|.:||.|||.||.|:|||.:.|||.|:||||:.||.||.:|||:|||:||.|||
Zfish    66 AEGRITRSSERFNELVCNYNTDIDFKDEERSNADRFMTKRCKDCLNKLAIAVMNQWPGVRLRVTE 130

  Fly   187 SWDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSI 251
            :||||.||...|||||||||.|.|||||..|||:||:||||||||||.|.|:.|::||||:|.|:
Zfish   131 AWDEDGHHPPGSLHYEGRAVDITTSDRDTKKYGLLAQLAVEAGFDWVHYESKYHVHCSVKADHSV 195

  Fly   252 SSHVHGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLH 316
            :....|||:......:..||:||:..|..|::|||::.:|:.|:|.|:||:..:.|...:|..:.
Zfish   196 AVEKGGCFSASGLVTMADGVQKPMSCLWPGEKVLSVSGSGEVVFSRVLLFLHLDRESRTSFFIIT 260

  Fly   317 TDGGAVLTVTPAHLVSVWQPESQKL-----TFVFADRIEEKNQVLVRDVETGELRPQRVVKVGSV 376
            |:....:.:||.||  ::...:.||     ..|||..:...:.:|....:.| ::|.:||.|...
Zfish   261 TENEKRIALTPNHL--IFAAHNLKLHHHDYETVFARNVRIGDYILTTGGDRG-IQPSKVVSVSLE 322

  Fly   377 RSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLL--------------------- 420
            ...||.||||..|.:.|:.|.||.||......|||....|.|:|
Zfish   323 ERMGVYAPLTEHGNLFVDGVLASNYATFQDHGLAHTVFWPFRVLFVFFNKEMEEDLQRVAVPYIC 387

  Fly   421 STLEAWLPAKEQLHSSPKVVSSAQ------------QQNGIHWYANALYKV-KDYVLPQ 466
            ||.:..|.:  .:||....|...|            ||..::|||..|:.: :.::.||
Zfish   388 STNQTILTS--VMHSRLSSVFKWQDATRAEMENAFLQQKEVYWYARLLHTLGRIFLDPQ 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	85..243	CDD:460055	99/158 (63%)
		Hint	254..465	CDD:460051	68/249 (27%)
dhh	NP_001025286.2	HH_signal	37..188	CDD:460055	93/150 (62%)
		Hint	190..442	CDD:460051	71/256 (28%)