DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hh and IHH

DIOPT Version :9

Sequence 1:	NP_001034065.1	Gene:	hh / 42737	FlyBaseID:	FBgn0004644	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_002172.2	Gene:	IHH / 3549	HGNCID:	5956	Length:	411	Species:	Homo sapiens

Alignment Length:	412	Identity:	189/412 - (45%)
Similarity:	250/412 - (60%)	Gaps:	31/412 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LVALLLIVLPMVFSPAHSCGPGRGLGRHR--ARNLYPLVLKQTIPNLSEYTNSASGPLEGVIRRD 129
            ||.|||:|:|    .|..|||||.:|..|  .|.|.||..||..||:.|.|..|||..||.|.|.
Human    14 LVLLLLLVVP----AAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARS 74

  Fly   130 SPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDEDYHH 194
            |.:||:|.||||.||:|:|||.|||||||::|||::||.||.||||:|||::|.|||.||||.||
Human    75 SERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHH 139

  Fly   195 GQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCF 259
            .:||||||||||.|.|||||::|||:|||||||||||||.|.|:.|::|||||:.|.::...|||
Human   140 SEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCF 204

  Fly   260 TPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHT-DGGAVL 323
            ...:...||||.|..|..:..|||||:|..:|...:|:|::|:||...:::.|..:.| |....|
Human   205 PAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTFSDVLIFLDREPHRLRAFQVIETQDPPRRL 269

  Fly   324 TVTPAHLVSVWQPESQ---KLTFVFADRIEEKNQVLVRDVETGELRPQRVVKVGSVRSKGVVAPL 385
            .:|||||:......::   :....||..::....|||..|.  .|:|.||..|.:..:.|..|||
Human   270 ALTPAHLLFTADNHTEPAARFRATFASHVQPGQYVLVAGVP--GLQPARVAAVSTHVALGAYAPL 332

  Fly   386 TREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLE--AWLPAKEQLHSSPKVVSSAQQQNG 448
            |:.||:||..|.|||:|.:....||.....|:||..:|.  :|.|.:                 |
Human   333 TKHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFHSLAWGSWTPGE-----------------G 380

  Fly   449 IHWYANALYKVKDYVLPQSWRH 470
            :|||...||::...:|.:...|
Human   381 VHWYPQLLYRLGRLLLEEGSFH 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432	96/143 (67%)
		Hint	254..465	CDD:279426	69/216 (32%)
		Hint	258..400	CDD:238035	51/145 (35%)
IHH	NP_002172.2	HH_signal	44..189	CDD:279432	96/144 (67%)
		Hint	192..386	CDD:279426	69/212 (33%)
		Hint	203..347	CDD:238035	51/145 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2389
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2177
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50028
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	1	1.000	-	-		FOG0001612
OrthoInspector	1	1.000	-	-		otm41846
orthoMCL	1	0.900	-	-		OOG6_104977
Panther	1	1.100	-	-	LDO	PTHR11889
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840