Protein Alignment hh and shhb

DIOPT Version :10

• Sequence 1: NP_001034065.1
• Gene: hh / 42737
• FlyBaseID: FBgn0004644
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_571274.2
• Gene: shhb / 30444
• ZFINID: ZDB-GENE-980526-41
• Length: 416
• Species: Danio rerio
• Alignment Length: 406
• Identity: 193/406 - (47%)
• Similarity: 263/406 - (64%)
• Gaps: 15/406 - (3%)

  Fly    71 LLIVLPMVFSPAH-SCGPGRGLGRHR-ARNLYPLVLKQTIPNLSEYTNSASGPLEGVIRRDSPKF 133
            ||..:.::.:|.. :||||||.|:.| .:.|.||..||.|||::|.|..|||..||.|.|:|.:|
Zfish    12 LLCFISLLLTPCGLACGPGRGYGKRRHPKKLTPLAYKQFIPNVAEKTLGASGKYEGKITRNSERF 76

  Fly   134 KDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDEDYHHGQES 198
            |:|:||||.||:|:|||.|.|||||:||||:|||.||.||||.|||::|.|||.||||..|.:||
Zfish    77 KELIPNYNPDIIFKDEENTNADRLMTKRCKDKLNSLAISVMNHWPGVKLRVTEGWDEDGRHLEES 141

  Fly   199 LHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPES 263
            ||||||||.|.|||||:||||||:|||||||||||.|.|:.||:||||:::|:::...|||....
Zfish   142 LHYEGRAVDITTSDRDKSKYGMLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSG 206

  Fly   264 TALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHT-DGGAVLTVTP 327
            |..|..|.|||:.:|.:|||||:....|..:.|:.|:|:|.:....:.|:.:.| :....||:|.
Zfish   207 TVTLGDGTRKPIKDLKVGDRVLAADEKGNVLISDFIMFIDHDPTTRRQFIVIETSEPFTKLTLTA 271

  Fly   328 AHLVSVWQPESQK-LTFVFADRIEEKNQVLVRDVETGELRPQRVVKVGSVRSKGVVAPLTREGTI 391
            ||||.|....:.. :|..||..::..:.|||.:.....|:...|.::.:...:|..||:|..|||
Zfish   272 AHLVFVGNSSAASGITATFASNVKPGDTVLVWEDTCESLKSVTVKRIYTEEHEGSFAPVTAHGTI 336

  Fly   392 VVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWL-PAKEQLHSSPKVVSSAQ-QQNGIHWYAN 454
            :|:.|.|||||||.:...|||..||:||...|..|| ||:|         |:.. |::|||||:|
Zfish   337 IVDQVLASCYAVIENHKWAHWAFAPVRLCHKLMTWLFPARE---------SNVNFQEDGIHWYSN 392

  Fly   455 ALYKVKDYVLPQSWRH 470
            .|:.:..::|.:...|
Zfish   393 MLFHIGSWLLDRDSFH 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	85..243	CDD:460055	107/158 (68%)
		Hint	254..465	CDD:460051	76/214 (36%)
shhb	NP_571274.2	HH_signal	27..187	CDD:460055	107/159 (67%)
		Hint	189..403	CDD:460051	78/222 (35%)