DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hh and shhb

DIOPT Version :9

Sequence 1:	NP_001034065.1	Gene:	hh / 42737	FlyBaseID:	FBgn0004644	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_571274.2	Gene:	shhb / 30444	ZFINID:	ZDB-GENE-980526-41	Length:	416	Species:	Danio rerio

Alignment Length:	406	Identity:	193/406 - (47%)
Similarity:	263/406 - (64%)	Gaps:	15/406 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 LLIVLPMVFSPAH-SCGPGRGLGRHR-ARNLYPLVLKQTIPNLSEYTNSASGPLEGVIRRDSPKF 133
            ||..:.::.:|.. :||||||.|:.| .:.|.||..||.|||::|.|..|||..||.|.|:|.:|
Zfish    12 LLCFISLLLTPCGLACGPGRGYGKRRHPKKLTPLAYKQFIPNVAEKTLGASGKYEGKITRNSERF 76

  Fly   134 KDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDEDYHHGQES 198
            |:|:||||.||:|:|||.|.|||||:||||:|||.||.||||.|||::|.|||.||||..|.:||
Zfish    77 KELIPNYNPDIIFKDEENTNADRLMTKRCKDKLNSLAISVMNHWPGVKLRVTEGWDEDGRHLEES 141

  Fly   199 LHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPES 263
            ||||||||.|.|||||:||||||:|||||||||||.|.|:.||:||||:::|:::...|||....
Zfish   142 LHYEGRAVDITTSDRDKSKYGMLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSG 206

  Fly   264 TALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHT-DGGAVLTVTP 327
            |..|..|.|||:.:|.:|||||:....|..:.|:.|:|:|.:....:.|:.:.| :....||:|.
Zfish   207 TVTLGDGTRKPIKDLKVGDRVLAADEKGNVLISDFIMFIDHDPTTRRQFIVIETSEPFTKLTLTA 271

  Fly   328 AHLVSVWQPESQK-LTFVFADRIEEKNQVLVRDVETGELRPQRVVKVGSVRSKGVVAPLTREGTI 391
            ||||.|....:.. :|..||..::..:.|||.:.....|:...|.::.:...:|..||:|..|||
Zfish   272 AHLVFVGNSSAASGITATFASNVKPGDTVLVWEDTCESLKSVTVKRIYTEEHEGSFAPVTAHGTI 336

  Fly   392 VVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWL-PAKEQLHSSPKVVSSAQ-QQNGIHWYAN 454
            :|:.|.|||||||.:...|||..||:||...|..|| ||:|         |:.. |::|||||:|
Zfish   337 IVDQVLASCYAVIENHKWAHWAFAPVRLCHKLMTWLFPARE---------SNVNFQEDGIHWYSN 392

  Fly   455 ALYKVKDYVLPQSWRH 470
            .|:.:..::|.:...|
Zfish   393 MLFHIGSWLLDRDSFH 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432	99/143 (69%)
		Hint	254..465	CDD:279426	76/214 (36%)
		Hint	258..400	CDD:238035	47/143 (33%)
shhb	NP_571274.2	HH_signal	42..187	CDD:279432	99/144 (69%)
		Hint	190..403	CDD:279426	77/221 (35%)
		Hint	201..345	CDD:238035	47/143 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2380
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30961
Inparanoid	1	1.050	367	1.000	Inparanoid score	I2110
OMA	1	1.010	-	-		QHG50028
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	1	1.000	-	-		FOG0001612
OrthoInspector	1	1.000	-	-		otm25233
orthoMCL	1	0.900	-	-		OOG6_104977
Panther	1	1.100	-	-	O	PTHR11889
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840