Protein Alignment hh and ihhb

DIOPT Version :10

• Sequence 1: NP_001034065.1
• Gene: hh / 42737
• FlyBaseID: FBgn0004644
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_571163.1
• Gene: ihhb / 30299
• ZFINID: ZDB-GENE-980526-135
• Length: 412
• Species: Danio rerio
• Alignment Length: 423
• Identity: 187/423 - (44%)
• Similarity: 258/423 - (60%)
• Gaps: 36/423 - (8%)

  Fly    63 RLTSLVALLLIVLPMVFSPAH-SCGPGRGLGRHRA-RNLYPLVLKQTIPNLSEYTNSASGPLEGV 125
            ||::..|||...: :.||||: .||||||.|:.|. |.|.||..||..||::|.|..|||..||.
Zfish     2 RLSTAAALLTGFI-LAFSPAYDGCGPGRGYGKRRTPRKLTPLAYKQFSPNVAEKTLGASGRYEGK 65

  Fly   126 IRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDE 190
            :...|.:||:|.||||.||:|:|||.|||||:|::|||:|||.||.||||.|||:||.|||.|||
Zfish    66 VTPSSERFKELTPNYNPDIIFKDEENTGADRMMTQRCKDKLNSLAISVMNLWPGVRLRVTEGWDE 130

  Fly   191 DYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHV 255
            |..|.:||||||||||.|.|||||::||.||||||||||||||.|.|:.|::|||||:.|:::..
Zfish   131 DGLHSEESLHYEGRAVDITTSDRDRNKYRMLARLAVEAGFDWVYYESKGHVHCSVKSEHSVAAKT 195

  Fly   256 HGCFTPESTALLESGVRKPLGELSIGDRVLSMTAN---GQAVYSEVILFMDRNLEQMQNFVQLHT 317
            .|||...:...::.|..:.:.:|..||.||:...:   |..:||||:.|:||.....::|..:.|
Zfish   196 GGCFPGRALVTMKDGSHRQIRDLQAGDLVLASEGSDGTGDLIYSEVLTFLDRRPITQKHFYVIRT 260

  Fly   318 DGGAVLTVTPAHLVSV--------WQPESQKLTFVFADRIEEKNQVLVRDVETGELRPQ--RVVK 372
            :.||.:::|.|||:.:        .:|:...:..:||...:....:|:     |:||.:  ::..
Zfish   261 EDGASVSLTAAHLLFMRVGNCSNRGEPKPGAVRTIFASDAQVGQCLLL-----GKLRKRFSQITH 320

  Fly   373 VGSVRSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWLPAKEQLHSSP 437
            ||....:|:..|||..||:|||.|..||||.:|.|.||||..||:||   |.:|....:.|
Zfish   321 VGVREDQGLYPPLTAHGTVVVNDVLTSCYAAVNRQRLAHWAFAPLRL---LYSWTGPDQVL---- 378

  Fly   438 KVVSSAQQQNGIHWYANALYKVKDYVLPQSWRH 470
                    :||:|||:..|..:...:|.....|
Zfish   379 --------KNGLHWYSQVLIGLGKLLLDSELFH 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	85..243	CDD:460055	103/158 (65%)
		Hint	254..465	CDD:460051	67/223 (30%)
ihhb	NP_571163.1	HH_signal	24..184	CDD:460055	103/159 (65%)
		Hint	186..398	CDD:460051	70/231 (30%)