DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hh and ihhb

DIOPT Version :9

Sequence 1:	NP_001034065.1	Gene:	hh / 42737	FlyBaseID:	FBgn0004644	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_571163.1	Gene:	ihhb / 30299	ZFINID:	ZDB-GENE-980526-135	Length:	412	Species:	Danio rerio

Alignment Length:	423	Identity:	187/423 - (44%)
Similarity:	258/423 - (60%)	Gaps:	36/423 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 RLTSLVALLLIVLPMVFSPAH-SCGPGRGLGRHRA-RNLYPLVLKQTIPNLSEYTNSASGPLEGV 125
            ||::..|||...: :.||||: .||||||.|:.|. |.|.||..||..||::|.|..|||..||.
Zfish     2 RLSTAAALLTGFI-LAFSPAYDGCGPGRGYGKRRTPRKLTPLAYKQFSPNVAEKTLGASGRYEGK 65

  Fly   126 IRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDE 190
            :...|.:||:|.||||.||:|:|||.|||||:|::|||:|||.||.||||.|||:||.|||.|||
Zfish    66 VTPSSERFKELTPNYNPDIIFKDEENTGADRMMTQRCKDKLNSLAISVMNLWPGVRLRVTEGWDE 130

  Fly   191 DYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHV 255
            |..|.:||||||||||.|.|||||::||.||||||||||||||.|.|:.|::|||||:.|:::..
Zfish   131 DGLHSEESLHYEGRAVDITTSDRDRNKYRMLARLAVEAGFDWVYYESKGHVHCSVKSEHSVAAKT 195

  Fly   256 HGCFTPESTALLESGVRKPLGELSIGDRVLSMTAN---GQAVYSEVILFMDRNLEQMQNFVQLHT 317
            .|||...:...::.|..:.:.:|..||.||:...:   |..:||||:.|:||.....::|..:.|
Zfish   196 GGCFPGRALVTMKDGSHRQIRDLQAGDLVLASEGSDGTGDLIYSEVLTFLDRRPITQKHFYVIRT 260

  Fly   318 DGGAVLTVTPAHLVSV--------WQPESQKLTFVFADRIEEKNQVLVRDVETGELRPQ--RVVK 372
            :.||.:::|.|||:.:        .:|:...:..:||...:....:|:     |:||.:  ::..
Zfish   261 EDGASVSLTAAHLLFMRVGNCSNRGEPKPGAVRTIFASDAQVGQCLLL-----GKLRKRFSQITH 320

  Fly   373 VGSVRSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWLPAKEQLHSSP 437
            ||....:|:..|||..||:|||.|..||||.:|.|.||||..||:||   |.:|....:.|
Zfish   321 VGVREDQGLYPPLTAHGTVVVNDVLTSCYAAVNRQRLAHWAFAPLRL---LYSWTGPDQVL---- 378

  Fly   438 KVVSSAQQQNGIHWYANALYKVKDYVLPQSWRH 470
                    :||:|||:..|..:...:|.....|
Zfish   379 --------KNGLHWYSQVLIGLGKLLLDSELFH 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432	94/143 (66%)
		Hint	254..465	CDD:279426	67/223 (30%)
		Hint	258..400	CDD:238035	43/154 (28%)
ihhb	NP_571163.1	HH_signal	39..184	CDD:279432	94/144 (65%)
		Hint	187..398	CDD:279426	69/230 (30%)
		Hint	198..348	CDD:238035	43/154 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573905
Domainoid	1	1.000	230	1.000	Domainoid score	I2380
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	367	1.000	Inparanoid score	I2110
OMA	1	1.010	-	-		QHG50028
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	1	1.000	-	-		FOG0001612
OrthoInspector	1	1.000	-	-		otm25233
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11889
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1177
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870