DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hh and shha

DIOPT Version :9

Sequence 1:	NP_001034065.1	Gene:	hh / 42737	FlyBaseID:	FBgn0004644	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_571138.1	Gene:	shha / 30269	ZFINID:	ZDB-GENE-980526-166	Length:	418	Species:	Danio rerio

Alignment Length:	420	Identity:	194/420 - (46%)
Similarity:	271/420 - (64%)	Gaps:	20/420 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RCLSR--LTSLVALLLIVLPMVFSPAHSCGPGRGLGRHR-ARNLYPLVLKQTIPNLSEYTNSASG 120
            |.|:|  |.||:.|.|:|..:      :||||||.||.| .:.|.||..||.|||::|.|..|||
Zfish     2 RLLTRVLLVSLLTLSLVVSGL------ACGPGRGYGRRRHPKKLTPLAYKQFIPNVAEKTLGASG 60

  Fly   121 PLEGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVT 185
            ..||.|.|:|.:||:|.||||.||:|:|||.|||||||::|||:|||.||.||||.|||::|.||
Zfish    61 RYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNHWPGVKLRVT 125

  Fly   186 ESWDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSS 250
            |.||||.||.:||||||||||.|.|||||:||||.|:|||||||||||.|.|:.||:||||:::|
Zfish   126 EGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENS 190

  Fly   251 ISSHVHGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQL 315
            :::...|||...:...|:.|.:|.:.:|:.||:||:..:.|..|:|:.|:|.||:....:.|..:
Zfish   191 VAAKSGGCFPGSALVSLQDGGQKAVKDLNPGDKVLAADSAGNLVFSDFIMFTDRDSTTRRVFYVI 255

  Fly   316 HT-DGGAVLTVTPAHLVSVWQPESQKL---TFVFADRIEEKNQVLVRDVETGELRPQRVVKVGSV 376
            .| :....:|:|.|||:.|....::.|   |..:|..:....:|:|.| ::|:|:...|.::.:.
Zfish   256 ETQEPVEKITLTAAHLLFVLDNSTEDLHTMTAAYASSVRAGQKVMVVD-DSGQLKSVIVQRIYTE 319

  Fly   377 RSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWL-PAKEQLHSSPKVV 440
            ..:|..||:|..|||||:.:.|||||||..|.|||...||.||...:.::| |......|
Zfish   320 EQRGSFAPVTAHGTIVVDRILASCYAVIEDQGLAHLAFAPARLYYYVSSFLFPQNSSSRS----- 379

  Fly   441 SSAQQQNGIHWYANALYKVKDYVLPQSWRH 470
            ::..||.|:|||:..||::..::|..:..|
Zfish   380 NATLQQEGVHWYSRLLYQMGTWLLDSNMLH 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432	99/143 (69%)
		Hint	254..465	CDD:279426	70/215 (33%)
		Hint	258..400	CDD:238035	44/145 (30%)
shha	NP_571138.1	Cardin-Weintraub. /evidence=ECO:0000250\|UniProtKB:Q62226	32..38		2/5 (40%)
		HH_signal	39..184	CDD:279432	99/144 (69%)
		Hint	187..404	CDD:279426	71/222 (32%)
		Hint	198..343	CDD:238035	44/145 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2380
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30961
Inparanoid	1	1.050	367	1.000	Inparanoid score	I2110
OMA	1	1.010	-	-		QHG50028
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	1	1.000	-	-		FOG0001612
OrthoInspector	1	1.000	-	-		otm25233
orthoMCL	1	0.900	-	-		OOG6_104977
Panther	1	1.100	-	-	O	PTHR11889
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840