DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hh and Shh

DIOPT Version :9

Sequence 1:	NP_001034065.1	Gene:	hh / 42737	FlyBaseID:	FBgn0004644	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_058917.1	Gene:	Shh / 29499	RGDID:	3673	Length:	437	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	202/432 - (46%)
Similarity:	266/432 - (61%)	Gaps:	30/432 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RCLSRLTSLVALLLIVLPMVFSPAHSCGPGRGLG-RHRARNLYPLVLKQTIPNLSEYTNSASGPL 122
            ||.  |.:|.:.||:      .|..:||||||.| |...:.|.||..||.|||::|.|..|||..
  Rat     7 RCF--LVALASSLLV------CPGLACGPGRGFGKRQHPKKLTPLAYKQFIPNVAEKTLGASGRY 63

  Fly   123 EGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTES 187
            ||.|.|:|.:||:|.||||.||:|:|||.|||||||::|||:|||.||.||||:|||::|.|||.
  Rat    64 EGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEG 128

  Fly   188 WDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSIS 252
            ||||.||.:||||||||||.|.|||||:||||||||||||||||||.|.|:..|:||||:::|::
  Rat   129 WDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKARIHCSVKAENSVA 193

  Fly   253 SHVHGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHT 317
            :...|||...:|..||.|..|.:.:||.|||||:....|:.:||:.:.|:||:....:.|..:.|
  Rat   194 AKSDGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIET 258

  Fly   318 -DGGAVLTVTPAHLVSVWQPESQK-----LTFVFADRIEEKNQVLVRDVETGELR--PQRVVKVG 374
             :....|.:|.|||:.| .|.:..     .:.:||.|:....:|.|.....|:.|  |..|..|
  Rat   259 REPRERLLLTAAHLLFV-APHNDSGPTPGPSPLFASRVRPGQRVYVVAERGGDRRLLPAAVHSV- 321

  Fly   375 SVRSK--GVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWL-PAKEQ---- 432
            ::|.:  |..||||.:|||::|.|.|||||||...|.||...||.||...|.|.| ||:..
  Rat   322 TLREEAAGAYAPLTADGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGG 386

  Fly   433 -LHSSPKVVSSAQQQN---GIHWYANALYKVKDYVLPQSWRH 470
             ...:|:.|:.|:...   |||||:..||.:..::|.....|
  Rat   387 GSIPAPQSVAEARGAGPPAGIHWYSQLLYHIGTWLLDSETLH 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432	100/143 (70%)
		Hint	254..465	CDD:279426	80/229 (35%)
		Hint	258..400	CDD:238035	51/151 (34%)
Shh	NP_058917.1	Cardin-Weintraub. /evidence=ECO:0000250\|UniProtKB:Q62226	33..39		1/5 (20%)
		HH_signal	40..185	CDD:279432	100/144 (69%)
		Hint	188..423	CDD:279426	81/236 (34%)
		Hint	199..349	CDD:238035	51/151 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2361
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30961
Inparanoid	1	1.050	358	1.000	Inparanoid score	I2150
OMA	1	1.010	-	-		QHG50028
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	1	1.000	-	-		FOG0001612
OrthoInspector	1	1.000	-	-		otm45983
orthoMCL	1	0.900	-	-		OOG6_104977
Panther	1	1.100	-	-	O	PTHR11889
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1177
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840