Protein Alignment hh and Shh

DIOPT Version :10

• Sequence 1: NP_001034065.1
• Gene: hh / 42737
• FlyBaseID: FBgn0004644
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_033196.1
• Gene: Shh / 20423
• MGIID: 98297
• Length: 437
• Species: Mus musculus
• Alignment Length: 432
• Identity: 198/432 - (45%)
• Similarity: 261/432 - (60%)
• Gaps: 30/432 - (6%)

  Fly    59 RCLSRLTSLVALLLIVLPMVFSPAHSCGPGRGLGRHR-ARNLYPLVLKQTIPNLSEYTNSASGPL 122
            ||.        |:::...::..|..:||||||.|:.| .:.|.||..||.|||::|.|..|||..
Mouse     7 RCF--------LVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRY 63

  Fly   123 EGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTES 187
            ||.|.|:|.:||:|.||||.||:|:|||.|||||||::|||:|||.||.||||:|||::|.|||.
Mouse    64 EGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEG 128

  Fly   188 WDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSIS 252
            ||||.||.:||||||||||.|.|||||:||||||||||||||||||.|.|:.||:||||:::|::
Mouse   129 WDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVA 193

  Fly   253 SHVHGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHT 317
            :...|||...:|..||.|..|.:.:|..|||||:....|:.:||:.:.|:||:....:.|..:.|
Mouse   194 AKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIET 258

  Fly   318 -DGGAVLTVTPAHLVSVWQPESQK-----LTFVFADRIEEKNQVLVRDVETGELR--PQRVVKVG 374
             :....|.:|.|||:.| .|.:..     .:.:||.|:....:|.|.....|:.|  |..|..|
Mouse   259 LEPRERLLLTAAHLLFV-APHNDSGPTPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSV- 321

  Fly   375 SVRSK--GVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWL-PAKEQ---- 432
            ::|.:  |..||||..|||::|.|.|||||||...|.||...||.||...|.|.| ||:..
Mouse   322 TLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGG 386

  Fly   433 ----LHSSPKVVSSAQQQNGIHWYANALYKVKDYVLPQSWRH 470
                ...|......|:...|||||:..||.:..::|.....|
Mouse   387 GSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMH 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	85..243	CDD:460055	109/158 (69%)
		Hint	254..465	CDD:460051	78/229 (34%)
Shh	NP_033196.1	HH_signal	25..185	CDD:460055	109/159 (69%)
		Cardin-Weintraub. /evidence=ECO:0000269|PubMed:23118222	33..39		1/5 (20%)
		Hint	187..423	CDD:460051	80/237 (34%)