DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hh and wrt-4

DIOPT Version :9

Sequence 1:	NP_001034065.1	Gene:	hh / 42737	FlyBaseID:	FBgn0004644	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_510593.1	Gene:	wrt-4 / 181664	WormBaseID:	WBGene00006950	Length:	557	Species:	Caenorhabditis elegans

Alignment Length:	226	Identity:	55/226 - (24%)
Similarity:	106/226 - (46%)	Gaps:	36/226 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 CFTPESTALLESGVRKPLGELSIGDRVLSMTANG-QAVYSEVILFMDRNLEQMQNFVQLHTDGGA 321
            ||..::...:.:|..|.:.||::||.|.::..|| |..:..|..::.|:.:|:.:||:...|.|.
Worm   346 CFPGDAMVNVYNGGFKRMDELAVGDWVQALDKNGSQVTFIPVQYWLHRDPKQVADFVEFTLDNGE 410

  Fly   322 VLTVTPAHLVSVWQ---PESQKLTF----VFADRI----------EEKNQVLVRDVETGELRPQR 369
            ..::|..|||.|.|   |.|:....    |.|:|:          .:|:|:..|         .:
Worm   411 TFSLTEKHLVFVTQCSVPYSEDENINANPVPAERVNIGDCFYIAHRKKSQMYQR---------VK 466

  Fly   370 VVKVGSVRSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWLPAKEQLH 434
            |:.:..|:..|:.:|:|..|.::|:.:.|||::..::.||.:      ...:.:..|   |.|:.
Worm   467 VLDINIVQKTGIYSPMTSRGHLLVDRIHASCHSETDNYSLQN------TFFTNVLRW---KSQIR 522

  Fly   435 SSPKVVSSAQQQNGIHWYANALYKVKDYVLP 465
            :....|..:..::.|.:..|.:..|.|.|:|
Worm   523 NYFWTVEDSTNEDNIGYGLNGVMAVLDIVIP 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432
		Hint	254..465	CDD:279426	54/224 (24%)
		Hint	258..400	CDD:238035	41/159 (26%)
wrt-4	NP_510593.1	Hint	342..547	CDD:279426	51/218 (23%)
wrt-4	NP_510593.1	Hint	346..497	CDD:238035	41/159 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S4101
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14084
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.700