DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hh and wrt-8

DIOPT Version :9

Sequence 1:	NP_001034065.1	Gene:	hh / 42737	FlyBaseID:	FBgn0004644	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_506805.1	Gene:	wrt-8 / 180035	WormBaseID:	WBGene00006954	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	168	Identity:	42/168 - (25%)
Similarity:	78/168 - (46%)	Gaps:	21/168 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 VHGCFTPESTA-LLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTD 318
            :|.||..::.. :.|.||:: :.||.:||.|.::... :..||.|..::.|:.||...||:...:
Worm   339 LHYCFPADAEVNVYEKGVKR-MDELEVGDWVQALHGK-ETTYSPVKYWLHRDPEQEAEFVEFLLE 401

  Fly   319 GGAVLTVTPAHLVSVWQPESQKLTFVFADRIEEKNQVLVRDVETGE----LRPQ--------RVV 371
            .|...|:|..|||.....:..      ...:::.|......:..||    .:|:        :::
Worm   402 NGESFTLTEKHLVFATDCQQN------VKNLDDLNPTSTGKINIGECFFMAQPENASKFQKVQIL 460

  Fly   372 KVGSVRSKGVVAPLTREGTIVVNSVAASCYAVINSQSL 409
            .:..||..|:.||:|..|.::||.:..||::.|:...|
Worm   461 DIQRVRKTGIYAPMTSLGHLLVNQIHTSCHSEIDHHLL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432
		Hint	254..465	CDD:279426	42/168 (25%)
		Hint	258..400	CDD:238035	37/154 (24%)
wrt-8	NP_506805.1	Hint	330..544	CDD:279426	42/168 (25%)
		HintN	341..446	CDD:197642	27/112 (24%)
		HintC	452..495	CDD:197641	12/42 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156257
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S4101
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14084
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.700