DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hh and qua-1

DIOPT Version :9

Sequence 1:	NP_001034065.1	Gene:	hh / 42737	FlyBaseID:	FBgn0004644	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_495725.2	Gene:	qua-1 / 174319	WormBaseID:	WBGene00004264	Length:	1169	Species:	Caenorhabditis elegans

Alignment Length:	167	Identity:	51/167 - (30%)
Similarity:	88/167 - (52%)	Gaps:	16/167 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 CFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTDGGAV 322
            ||:.:|.....:| :|.:.||.|||.||..::.....|.:|.:|..|..:...|||.|:|..|..
Worm   961 CFSADSLVTTVTG-QKRMDELQIGDYVLVPSSGNVLKYEKVEMFYHREPKTRTNFVVLYTKSGRK 1024

  Fly   323 LTVTPAHLVSV----------WQPESQKLTF---VFADRIEEKNQVLVRDVETGELRPQRVVKVG 374
            |::|..||:.|          ..|:...:..   .:|::..:...||..| |:||:....:|:||
Worm  1025 LSLTGRHLLPVAECSQVEQYTMNPDGIDVAMRESKYAEKARKGECVLSID-ESGEVIADEIVRVG 1088

  Fly   375 SVRSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAH 411
            .:.:.|:.:|:|.||:::|:.|.:||::.:.|.| ||
Worm  1089 RMTNVGIYSPMTVEGSLIVDGVLSSCFSHLESHS-AH 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432
		Hint	254..465	CDD:279426	51/167 (31%)
		Hint	258..400	CDD:238035	45/154 (29%)
qua-1	NP_495725.2	Hint	961..1114	CDD:238035	45/154 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I5947
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S4101
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14084
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.720