Protein Alignment hh and Dhh

DIOPT Version :9

• Sequence 1: NP_001034065.1
• Gene: hh / 42737
• FlyBaseID: FBgn0004644
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_031883.1
• Gene: Dhh / 13363
• MGIID: 94891
• Length: 396
• Species: Mus musculus
• Alignment Length: 408
• Identity: 200/408 - (49%)
• Similarity: 260/408 - (63%)
• Gaps: 26/408 - (6%)

  Fly    64 LTSLVALLLIVLPMVFSPAHSCGPGRG-LGRHR--ARNLYPLVLKQTIPNLSEYTNSASGPLEGV 125
            |..|..|.|:.|     .|.||||||| :||.|  .:.|.||:.||.:|::.|.|..||||.||.
Mouse     7 LLPLCCLALLAL-----SAQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSMPERTLGASGPAEGR 66

  Fly   126 IRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDE 190
            :.|.|.:|:|||||||.||:|:|||.:||||||::||||::|.||.:|||.|||:||.|||.|||
Mouse    67 VTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDE 131

  Fly   191 DYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHV 255
            |.||.|:||||||||:.|.|||||::|||:|||||||||||||.|.||.||:.|||:|:|::...
Mouse   132 DGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVSVKADNSLAVRA 196

  Fly   256 HGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTD-G 319
            .|||...:|..|.||.||.|.||..||.||:..|.|:.|.:.|:||:||:|::..:||.:.|: .
Mouse   197 GGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERP 261

  Fly   320 GAVLTVTPAHLVSVWQ---PESQKLTFVFADRIEEKNQVLVRDVETGELRPQRVVKVGSVRSKGV 381
            ...|.:||.|||...:   |.......|||.|:...:.||....:.  |:|.||.:|....:.||
Mouse   262 PRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDA--LQPARVARVAREEAVGV 324

  Fly   382 VAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWLPAKEQLHSSPKVVSSAQQQ 446
            .||||..||::||.|.||||||:.|...||...||:|||..|.|.||            ..|.|.
Mouse   325 FAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLP------------GGAVQP 377

  Fly   447 NGIHWYANALYKVKDYVL 464
            .|:|||:..||::.:.::
Mouse   378 TGMHWYSRLLYRLAEELM 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hh	NP_001034065.1	HH_signal	99..243	CDD:279432	96/143 (67%)
		Hint	254..465	CDD:279426	83/215 (39%)
		Hint	258..400	CDD:238035	57/145 (39%)
Dhh	NP_031883.1	HH_signal	40..185	CDD:307298	96/144 (67%)
		Hint	188..395	CDD:307293	85/220 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833639
Domainoid	1	1.000	234	1.000	Domainoid score	I2377
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	358	1.000	Inparanoid score	I2207
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50028
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	1	1.000	-	-		FOG0001612
OrthoInspector	1	1.000	-	-		otm43895
orthoMCL	1	0.900	-	-		OOG6_104977
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4415
SonicParanoid	1	1.000	-	-		X1177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.700