DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZBTB5

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_055687.1	Gene:	ZBTB5 / 9925	HGNCID:	23836	Length:	677	Species:	Homo sapiens

Alignment Length:	598	Identity:	111/598 - (18%)
Similarity:	174/598 - (29%)	Gaps:	253/598 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 EEQAAEMHKRLVKSRL----------------ELRAKLTTELRKELAEEV-----RSEVRKELAE 184
            :||:|.|.:..:..:|                |..|.:::.:|..|.:..     |...||:.||
Human   134 QEQSARMQRSFMLQQLGLSIVSSALNSSQNGEEQPAPMSSSMRSNLDQRTPFPMRRLHKRKQSAE 198

  Fly   185 EVRSQVRDDLRNEVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPETKP----QVKEDAS 245
            |   :.|..||..:.|                          .::....||..|    ..:|..|
Human   199 E---RARQRLRPSIDE--------------------------SAISDVTPENGPSGVHSREEFFS 234

  Fly   246 PSRSKTKALPKRRPSLVDANLKATEARKDAKEEEFILGCNTDPANNSDVNID---GLELDEEVPA 307
            |...|          :|| |.||...              ||...:|.:..|   |.:.|.:||:
Human   235 PDSLK----------IVD-NPKADGM--------------TDNQEDSAIMFDQSFGTQEDAQVPS 274

  Fly   308 ESGEDFREINMVGSDVVHTDN--GEIYIINSASSEDQ-----NQDSTPE---FDQDNGITSYNIK 362
            :|                 ||  |.:..::.||...|     :|::.||   |..:|.......|
Human   275 QS-----------------DNSAGNMAQLSMASRATQVETSFDQEAAPEKSSFQCENPEVGLGEK 322

  Fly   363 E---------------------DGEIQFSGEKPEEIEDVVVFNLGEEISQEQQVFSFHE------ 400
            |                     |...|..|.:..|:|.|||.....::|.|....||.:
Human   323 EHMRVVVKSEPLSSPEPQDEVSDVTSQAEGSESVEVEGVVVSAEKIDLSPESSDRSFSDPQSSTD 387

  Fly   401 ---NVIIVEKEQNDRDEQT-----PLKRKRSSELVFKQ---------------ESSCP---QPKT 439
               ::.|:|...|...:.|     .|.:.|.:.....|               ||..|   .|:.
Human   388 RVGDIHILEVTNNLEHKSTFSISNFLNKSRGNNFTANQNNDDNIPNTTSDCRLESEAPYLLSPEA 452

  Fly   440 GRITDTVKSFQCHL-CPVAFPTQKLLTRHHNTHIKGL-------------------KSG------ 478
            |.......:...|: .|.:.|......|... .:.||                   :||
Human   453 GPAGGPSSAPGSHVENPFSEPADSHFVRPMQ-EVMGLPCVQTSGYQGGEQFGMDFSRSGLGLHSS 516

  Fly   479 ---------KGGTLKCP-----------------------SCALQL------------------- 492
                     :||....|                       |.:.||
Human   517 FSRVMIGSPRGGASNFPYYRRIAPKMPVVTSVRSSQIPENSTSSQLMMNGATSSFENGHPSQPGP 581

  Fly   493 ------------SCASSLKRH-MIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCPQC 544
                        .|..:|..| :::..|.:.:.|..|..:|......|:|:..|||.|.:.|.:|
Human   582 PQLTRASADVLSKCKKALSEHNVLVVEGARKYACKICCKTFLTLTDCKKHIRVHTGEKPYACLKC 646

  Fly   545 SSCFAQKSNLQQH 557
            ...|:|.|:|.:|
Human   647 GKRFSQSSHLYKH 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	23/127 (18%)
		RRF	<161..222	CDD:294170	12/65 (18%)
		zf-C2H2_8	454..530	CDD:292531	21/164 (13%)
		C2H2 Zn finger	485..505	CDD:275368	7/74 (9%)
		zf-H2C2_2	497..522	CDD:290200	6/25 (24%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	7/17 (41%)
		C2H2 Zn finger	571..591	CDD:275368
		C2H2 Zn finger	598..617	CDD:275368
ZBTB5	NP_055687.1	BTB	14..119	CDD:279045
		BTB	25..119	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..252		27/147 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..312		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..387		12/55 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..474		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..585		3/32 (9%)
		C2H2 Zn finger	615..635	CDD:275368	5/19 (26%)
		zf-H2C2_2	627..652	CDD:290200	9/24 (38%)
		C2H2 Zn finger	643..662	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000