DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31365 and ZNF845

DIOPT Version :10

Sequence 1:NP_732827.1 Gene:CG31365 / 42736 FlyBaseID:FBgn0051365 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_612383.1 Gene:ZNF845 / 91664 HGNCID:25112 Length:970 Species:Homo sapiens


Alignment Length:609 Identity:136/609 - (22%)
Similarity:224/609 - (36%) Gaps:165/609 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 QRCQWAEKKLRKHIRLLGLGKRSRVFSKD-------------PDDYDEDELEFEDSIAFIEVQDK 126
            ||..:.:..|..:..|:.|...|:...|:             .......|........|.|::..
Human    29 QRTLYRDVMLENYRNLVSLDISSKCMMKEFSSTAQGNTEVIHTGTLQRHERHHIGDFCFQEMEKD 93

  Fly   127 VRKLEDEKWREDFKEEQAAEMHKRLVKSRLELRAKLTTELRKELAEEVRSEVRKELAEEVRSQVR 191
            :...|.: |:||.:....|.|                ||:::......|.:.|....:.::.|:.
Human    94 IHDFEFQ-WKEDERNSHEAPM----------------TEIKQLTGSTNRHDQRHAGNKPIKDQLG 141

  Fly   192 DDLRNEVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPSRSKTKALPK 256
            ....:.             |.||.::.||.|.|.             ||::              
Human   142 SSFHSH-------------LPELHMFQTEGKIGN-------------QVEK-------------- 166

  Fly   257 RRPSLVDANLKATEARKDAKEEEFILGCNTDPANNSDVNIDGLELDEEVPA--------ESGEDF 313
               |:..|:|.:|..|...:.:..|    :....|:.:|...|...:||..        |||:.|
Human   167 ---SINSASLVSTSQRISCRPKTHI----SKNYGNNFLNSSLLTQKQEVHMREKSFQCNESGKAF 224

  Fly   314 --------REINMVGSDVVHTD------NGEIYI-----INSASSEDQNQDSTPEFDQDNGITSY 359
                    .:|..:|:.....|      |.:.|:     .::.....:..|....|.|:..:|.:
Human   225 NYSSVLRKHQIIHLGAKQYKCDVCGKVFNQKRYLACHRRCHTGKKPYKCNDCGKTFSQELTLTCH 289

  Fly   360 NIKEDGEIQF----------------------SGEKPEEIEDVVVFNLGEEISQEQQVFSFHENV 402
            :....||..:                      :|||..:..:     .|:..||...:. :|..:
Human   290 HRLHTGEKHYKCSECGKTFSRNSALVIHKAIHTGEKSYKCNE-----CGKTFSQTSYLV-YHRRL 348

  Fly   403 IIVEK----EQNDR--DEQTPLKRKRSSELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQ 461
            ...||    |:.|:  ..::.|:|.|...             ||.     |.::|:.|...|..:
Human   349 HTGEKPYKCEECDKAFSFKSNLERHRKIH-------------TGE-----KPYKCNECSRTFSRK 395

  Fly   462 KLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVL 526
            ..||||...| .|.|     ..||..|....|..|||..|..:|||.||:||.||:.:||.:..|
Human   396 SSLTRHRRLH-TGEK-----PYKCNDCGKTFSQMSSLVYHRRLHTGEKPYKCEECDEAFSFKSNL 454

  Fly   527 KRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTH 591
            :||...|||.|.::|..|...|:|.|:|..| .|:|.| .:.:||..|..:|:..|.|.||.:.|
Human   455 ERHRRIHTGEKPYKCNDCGKTFSQTSSLVYH-RRLHTG-EKPYKCEECDEAFSFKSNLERHRIIH 517

  Fly   592 AG-VMFSCKQCGRQFNDRSAVQRH 614
            .| .::.|.:||:.|:.:|::.||
Human   518 TGEKLYKCNECGKTFSRKSSLTRH 541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31365NP_732827.1 zf-AD 13..86 CDD:214871 3/10 (30%)
PTZ00121 <110..354 CDD:173412 46/270 (17%)
zf-C2H2_8 454..542 CDD:464935 35/87 (40%)
C2H2 Zn finger 485..505 CDD:275368 7/19 (37%)
zf-H2C2_2 497..522 CDD:463886 13/24 (54%)
C2H2 Zn finger 513..533 CDD:275368 8/19 (42%)
zf-H2C2_2 526..550 CDD:463886 10/23 (43%)
C2H2 Zn finger 541..562 CDD:275368 8/20 (40%)
C2H2 Zn finger 571..591 CDD:275368 7/19 (37%)
C2H2 Zn finger 598..617 CDD:275368 7/17 (41%)
ZNF845NP_612383.1 C2H2 Zn finger 581..601 CDD:275368
C2H2 Zn finger 609..629 CDD:275368
C2H2 Zn finger 637..657 CDD:275368
C2H2 Zn finger 665..685 CDD:275368
C2H2 Zn finger 693..713 CDD:275368
C2H2 Zn finger 721..741 CDD:275368
C2H2 Zn finger 749..769 CDD:275368
C2H2 Zn finger 777..797 CDD:275368
C2H2 Zn finger 805..825 CDD:275368
C2H2 Zn finger 833..853 CDD:275368
zf-H2C2_2 845..870 CDD:463886
C2H2 Zn finger 861..881 CDD:275368
zf-H2C2_2 873..898 CDD:463886
C2H2 Zn finger 889..909 CDD:275368
C2H2 Zn finger 917..937 CDD:275368
C2H2 Zn finger 945..965 CDD:275368
KRAB 7..48 CDD:460171 4/18 (22%)
COG5048 169..564 CDD:227381 105/409 (26%)
C2H2 Zn finger 217..237 CDD:275368 5/19 (26%)
C2H2 Zn finger 245..265 CDD:275368 3/19 (16%)
C2H2 Zn finger 273..293 CDD:275368 4/19 (21%)
C2H2 Zn finger 301..321 CDD:275368 0/19 (0%)
C2H2 Zn finger 329..349 CDD:275368 4/25 (16%)
C2H2 Zn finger 357..377 CDD:275368 5/19 (26%)
COG5048 381..813 CDD:227381 64/169 (38%)
C2H2 Zn finger 385..405 CDD:275368 7/19 (37%)
C2H2 Zn finger 413..433 CDD:275368 7/19 (37%)
C2H2 Zn finger 441..461 CDD:275368 8/19 (42%)
C2H2 Zn finger 469..489 CDD:275368 8/20 (40%)
C2H2 Zn finger 497..517 CDD:275368 7/19 (37%)
C2H2 Zn finger 525..545 CDD:275368 7/17 (41%)
C2H2 Zn finger 553..573 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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