DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF616

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_848618.2	Gene:	ZNF616 / 90317	HGNCID:	28062	Length:	781	Species:	Homo sapiens

Alignment Length:	395	Identity:	110/395 - (27%)
Similarity:	166/395 - (42%)	Gaps:	57/395 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 PQVKEDASPSRSKTKALPKRRPSLVDANLKATEARKDAKEEEFILGCNTDPANNSDVNIDGLELD 302
            |..:...:..|.:|.|| :|..|....||...|.:|...:.||...             ||...|
Human    58 PPTENSNTGERFQTVAL-ERHQSYDIENLYFREIQKHLHDLEFQWK-------------DGETND 108

  Fly   303 EEVPAESGEDFREINMVGSDVVHTDNGEI---YIINSASSEDQNQDSTPEFDQDNGITSYNIKED 364
            :|||..     .|.|:.|....|: .|::   :|.|..:|..:::.:..:..|..|    .:.|.
Human   109 KEVPVP-----HENNLTGKRDQHS-QGDVENNHIENQLTSNFESRLAELQKVQTEG----RLYEC 163

  Fly   365 GEIQFSGE-----KPEEIEDVVVFN-LGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRS 423
            .|.:.:|.     .|...|...|.| .|:.......:.: |:.:...||         |.|....
Human   164 NETEKTGNNGCLVSPHIREKTYVCNECGKAFKASSSLIN-HQRIHTTEK---------PYKCNEC 218

  Fly   424 SELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSC 488
            .: .|.:.|.....|.  :....||:||.:|...|.......||..:|     :|:...: |..|
Human   219 GK-AFHRASLLTVHKV--VHTRGKSYQCDVCGKIFRKNSYFVRHQRSH-----TGQKPYI-CNEC 274

  Fly   489 ALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSN 553
            ....|.:|.|..|..||||.||:||:.|..|||||..|:.|...|||.:..:|.:|...|.:.||
Human   275 GKSFSKSSHLAVHQRIHTGEKPYKCNLCGKSFSQRVHLRLHQTVHTGERPFKCNECGKTFKRSSN 339

  Fly   554 LQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAG-VMFSCKQCGRQFNDRS--AVQRHV 615
            |..| ..:|.| .:.:||.:|.::|.|.|.|..|...|:| ..:.|.:||:.|:.||  ||.|.:
Human   340 LTVH-QVIHAG-KKPYKCDVCGKAFRHRSNLVCHRRIHSGEKQYKCNECGKVFSKRSSLAVHRRI 402

  Fly   616 TTMHK 620
            .|:.|
Human   403 HTVEK 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	1/5 (20%)
		RRF	<161..222	CDD:294170
		zf-C2H2_8	454..530	CDD:292531	27/75 (36%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:290200	13/24 (54%)
		C2H2 Zn finger	513..533	CDD:275368	9/19 (47%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..617	CDD:275368	9/20 (45%)
ZNF616	NP_848618.2	KRAB	7..61	CDD:214630	1/2 (50%)
		KRAB	7..46	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..129		8/29 (28%)
		C2H2 Zn finger	187..207	CDD:275368	3/20 (15%)
		zf-H2C2_2	199..224	CDD:290200	6/35 (17%)
		C2H2 Zn finger	243..263	CDD:275368	5/19 (26%)
		COG5048	266..707	CDD:227381	55/145 (38%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:290200	13/24 (54%)
		C2H2 Zn finger	299..319	CDD:275368	9/19 (47%)
		zf-H2C2_2	311..336	CDD:290200	8/24 (33%)
		C2H2 Zn finger	327..347	CDD:275368	7/20 (35%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		C2H2 Zn finger	383..403	CDD:275368	9/19 (47%)
		C2H2 Zn finger	411..431	CDD:275368
		C2H2 Zn finger	439..459	CDD:275368
		C2H2 Zn finger	467..487	CDD:275368
		zf-H2C2_2	480..504	CDD:290200
		C2H2 Zn finger	495..515	CDD:275368
		zf-H2C2_2	508..531	CDD:290200
		C2H2 Zn finger	523..543	CDD:275368
		zf-H2C2_2	538..560	CDD:290200
		C2H2 Zn finger	551..571	CDD:275368
		C2H2 Zn finger	579..599	CDD:275368
		zf-H2C2_2	591..616	CDD:290200
		C2H2 Zn finger	607..627	CDD:275368
		zf-H2C2_2	620..644	CDD:290200
		C2H2 Zn finger	635..655	CDD:275368
		zf-H2C2_2	647..672	CDD:290200
		C2H2 Zn finger	663..683	CDD:275368
		C2H2 Zn finger	691..711	CDD:275368
		zf-H2C2_2	703..728	CDD:290200
		C2H2 Zn finger	719..739	CDD:275368
		zf-H2C2_2	731..754	CDD:290200
		C2H2 Zn finger	747..767	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910