DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF527

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_115829.1	Gene:	ZNF527 / 84503	HGNCID:	29385	Length:	609	Species:	Homo sapiens

Alignment Length:	589	Identity:	139/589 - (23%)
Similarity:	222/589 - (37%)	Gaps:	153/589 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 DEDELEFEDSIAFIEVQDKVRK--LEDEKWREDFKEEQAAEMHKRLVKSRLELRAKLTTELRKEL 170
            ||||:..|      .|.:::..  ||...:||.:|.:...|:|:
Human   103 DEDEISQE------MVMERLASHGLECSSFREAWKYKGEFELHQ--------------------- 140

  Fly   171 AEEVRSEVRKELAEEVRSQVRDDLRNEVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPE 235
            ....|..::....:|:.:..||   ||.|...|...|.      .|:||::|.          |.
Human   141 GNAERHFMQVTAVKEISTGKRD---NEFSNSGRSIPLK------SVFLTQQKV----------PT 186

  Fly   236 TKPQVKEDASPSRSKTKALPKRRPSLVDANLKATEARKDAKEEEFILGCNTDPANNS-----DVN 295
            .:...|.|.     ..|..|:        |....|.::...|:|.::|...:..|.|     |:.
Human   187 IQQVHKFDI-----YDKLFPQ--------NSVIIEYKRLHAEKESLIGNECEEFNQSTYLSKDIG 238

  Fly   296 IDGLELDEEVPAESGEDFREINMVGS-----DVVH--------TDNGEIYIINSASSEDQNQDST 347
            |.    ..|.|.|| .||.::....|     ...|        .:.|:.:...|..::.|...|
Human   239 IP----PGEKPYES-HDFSKLLSFHSLFTQHQTTHFGKLPHGYDECGDAFSCYSFFTQPQRIHS- 297

  Fly   348 PEFDQDNGITSYNIKEDGEIQFS-------------GEKPEEIEDV-VVFNLGEEISQEQQVF-- 396
                   |...|...:.|: .||             ||||.|.::. ..|.....::|.|::.
Human   298 -------GEKPYACNDCGK-AFSHDFFLSEHQRTHIGEKPYECKECNKAFRQSAHLAQHQRIHTG 354

  Fly   397 -----------SFHENVIIVEKEQNDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITDTVKSFQ 450
                       :|.....:||.::....|: |.:.|..:: .|:|.:...|.:  ||....|.::
Human   355 EKPFACNECGKAFSRYAFLVEHQRIHTGEK-PYECKECNK-AFRQSAHLNQHQ--RIHTGEKPYE 415

  Fly   451 CHLCPVAFPTQKLLTRHHNTHI--KGLKSGKGG--------------------TLKCPSCALQLS 493
            |:.|..||..:..||.|...|.  |..|..:.|                    ..:|..|.....
Human   416 CNQCGKAFSRRIALTLHQRIHTGEKPFKCSECGKTFGYRSHLNQHQRIHTGEKPYECIKCGKFFR 480

  Fly   494 CASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHI 558
            ..|.|.||..||||.:||:||:|..:||...||..|..:|.|.|.::|.:|...|:..|.|.||
Human   481 TDSQLNRHHRIHTGERPFECSKCGKAFSDALVLIHHKRSHAGEKPYECNKCGKAFSCGSYLNQH- 544

  Fly   559 GRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQCGRQFNDRSAVQRHVTTMHKVK 622
            .|:|.| .:.::|..|.::|:.:..|..|...|||.. :.|.:||..|:..||::||    .::.
Human   545 QRIHTG-EKPYECSECGKAFHQILSLRLHQRIHAGEKPYKCNECGNNFSCVSALRRH----QRIH 604

  Fly   623 NKLT 626
            |:.|
Human   605 NRET 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	27/136 (20%)
		RRF	<161..222	CDD:294170	12/60 (20%)
		zf-C2H2_8	454..530	CDD:292531	29/97 (30%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:290200	13/24 (54%)
		C2H2 Zn finger	513..533	CDD:275368	8/19 (42%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..617	CDD:275368	8/18 (44%)
ZNF527	NP_115829.1	KRAB	14..53	CDD:279668
		C2H2 Zn finger	222..240	CDD:275368	3/17 (18%)
		C2H2 Zn finger	252..268	CDD:275368	1/15 (7%)
		C2H2 Zn finger	277..296	CDD:275368	3/18 (17%)
		C2H2 Zn finger	304..324	CDD:275368	3/20 (15%)
		zf-H2C2_2	317..341	CDD:290200	6/23 (26%)
		COG5048	<328..490	CDD:227381	35/165 (21%)
		C2H2 Zn finger	332..352	CDD:275368	3/19 (16%)
		zf-H2C2_2	344..369	CDD:290200	3/24 (13%)
		C2H2 Zn finger	360..380	CDD:275368	3/19 (16%)
		zf-H2C2_2	373..397	CDD:290200	6/25 (24%)
		C2H2 Zn finger	388..408	CDD:275368	5/22 (23%)
		zf-H2C2_2	400..425	CDD:290200	8/26 (31%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		zf-H2C2_2	428..453	CDD:290200	7/24 (29%)
		C2H2 Zn finger	444..464	CDD:275368	1/19 (5%)
		zf-H2C2_2	456..481	CDD:290200	2/24 (8%)
		C2H2 Zn finger	472..492	CDD:275368	6/19 (32%)
		zf-H2C2_2	485..508	CDD:290200	12/22 (55%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		zf-H2C2_2	516..537	CDD:290200	7/20 (35%)
		C2H2 Zn finger	528..548	CDD:275368	8/20 (40%)
		zf-H2C2_2	540..565	CDD:290200	9/26 (35%)
		C2H2 Zn finger	556..576	CDD:275368	5/19 (26%)
		zf-H2C2_2	568..593	CDD:290200	9/24 (38%)
		C2H2 Zn finger	584..604	CDD:275368	8/23 (35%)
		KRAB	14..74	CDD:214630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910