DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF34

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_085057.3	Gene:	ZNF34 / 80778	HGNCID:	13098	Length:	560	Species:	Homo sapiens

Alignment Length:	512	Identity:	126/512 - (24%)
Similarity:	207/512 - (40%)	Gaps:	100/512 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 VRKLE--DEKWREDFKEEQAAEMHKRLVKSRLELRAKLTTELRKELAEEVRSEVRKELAEEVRSQ 189
            :.:||  ||.|..|.:.....| |.|:....|..|    ||.::..::|...|...:.:|.|
Human    86 ISQLERGDEPWVLDVQGTSGKE-HLRVNSPALGTR----TEYKELTSQETFGEEDPQGSEPV--- 142

  Fly   190 VRDDLRNEVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPSRSKTKAL 254
                   |..:.|.|.:     |.|| .|.|::..|..:|...|..     :|.....|..::.:
Human   143 -------EACDHISKSE-----GSLE-KLVEQRGPRAVTLTNGESS-----RESGGNLRLLSRPV 189

  Fly   255 PKRRPSLVDANLKATEARKDAKEEEFI-LGCNTDPANNS----DVNIDGLELDEEVP-------- 306
            |.:||...|...::.|.|......:.: ....|:...||    ..|:...| |:::|
Human   190 PDQRPHKCDICEQSFEQRSYLNNHKRVHRSKKTNTVRNSGEIFSANLVVKE-DQKIPTGKKLHYC 253

  Fly   307 AESGEDFR-EINMVGSDVVHTDNGEIYIINSASSEDQNQDSTPEFDQDNGITSYNIKEDGEIQFS 370
            :..|:.|| ..|:|....:||:. :.|..:....         .|.|.....::.....|||.:.
Human   254 SYCGKTFRYSANLVKHQRLHTEE-KPYKCDECGK---------AFSQSCEFINHRRMHSGEIPYR 308

  Fly   371 GEKPEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLK-------RKRSSELVF 428
            .::           .|:..::...:.. |:.:...||         |.|       ....|.|::
Human   309 CDE-----------CGKTFTRRPNLMK-HQRIHTGEK---------PYKCGECGKHFSAYSSLIY 352

  Fly   429 KQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLS 493
            .|          ||....|.::|:.|..||....:|.||..|| .|.|     ..:|..|....:
Human   353 HQ----------RIHTGEKPYKCNDCGKAFSDGSILIRHRRTH-TGEK-----PFECKECGKGFT 401

  Fly   494 CASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHI 558
            .:|:|.:|..||||.||:||:|||.:|.|:..|..|..:|||.|.::|..|...|:|.::|.||
Human   402 QSSNLIQHQRIHTGEKPYKCNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQSTHLIQH- 465

  Fly   559 GRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQCGRQFNDRSAVQRH 614
            .|:|.| .:.:||..|.::|::.|.|..|...|.|.. :.|..|.:.|:..:.:.:|
Human   466 QRIHTG-EKPYKCSECGKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQH 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	29/118 (25%)
		RRF	<161..222	CDD:294170	14/60 (23%)
		zf-C2H2_8	454..530	CDD:292531	29/75 (39%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		zf-H2C2_2	497..522	CDD:290200	14/24 (58%)
		C2H2 Zn finger	513..533	CDD:275368	8/19 (42%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	4/17 (24%)
ZNF34	NP_085057.3	KRAB	35..97	CDD:214630	4/10 (40%)
		KRAB	35..74	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..188		5/29 (17%)
		COG5048	188..554	CDD:227381	96/384 (25%)
		C2H2 Zn finger	197..217	CDD:275368	3/19 (16%)
		zf-C2H2	251..273	CDD:278523	5/21 (24%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		zf-H2C2_2	265..290	CDD:290200	6/34 (18%)
		C2H2 Zn finger	281..301	CDD:275368	2/28 (7%)
		zf-C2H2	307..329	CDD:278523	2/33 (6%)
		C2H2 Zn finger	309..329	CDD:275368	2/31 (6%)
		zf-H2C2_2	321..345	CDD:290200	5/33 (15%)
		C2H2 Zn finger	337..357	CDD:275368	4/29 (14%)
		zf-H2C2_2	349..373	CDD:290200	8/33 (24%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		zf-H2C2_2	378..402	CDD:290200	9/29 (31%)
		C2H2 Zn finger	393..413	CDD:275368	5/19 (26%)
		zf-H2C2_2	405..430	CDD:290200	14/24 (58%)
		C2H2 Zn finger	421..441	CDD:275368	8/19 (42%)
		zf-H2C2_2	434..458	CDD:290200	9/23 (39%)
		C2H2 Zn finger	449..469	CDD:275368	8/20 (40%)
		zf-H2C2_2	461..486	CDD:290200	10/26 (38%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		zf-H2C2_2	493..514	CDD:290200	6/20 (30%)
		C2H2 Zn finger	505..525	CDD:275368	4/17 (24%)
		zf-H2C2_2	517..542	CDD:290200	1/5 (20%)
		C2H2 Zn finger	533..553	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910