DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31365 and Mynn

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_085034.2	Gene:	Mynn / 80732	MGIID:	1931415	Length:	610	Species:	Mus musculus

Alignment Length:	638	Identity:	154/638 - (24%)
Similarity:	240/638 - (37%)	Gaps:	163/638 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 CRYQLEKSFLFRQR-----CQW----AEKKLRKHIRLLG-----LGKRSRVFSKDPDDYDEDELE 113
            |.:.||:  |.:||     |..    .|.:.:.|..:|.     .|...|..|::....|:.:::
Mouse     7 CEHLLER--LNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVK 69

  Fly   114 ---FEDSIAFIEVQDKVRKLEDEKWREDFKE-EQAAEMHKRLVKSRLELRAKLTTELRKELAEEV 174
               |:..:.||    ....|..:.|  :.|| .|||:..|                     .|||
Mouse    70 ADGFQKLLEFI----YTGTLNLDSW--NVKEIHQAADYLK---------------------VEEV 107

  Fly   175 --RSEVRKELAEEVRSQVRDDLRNEVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPETK 237
              :.:::.|....:.|....:: :.::.:|...|.|.|| .|..|...:|:.  .|.|..:...|
Mouse   108 VTKCKIKMEDFAFIASPSSTEI-SSITGNIELNQQACLL-TLRDYNNREKSE--VSTDSVQANPK 168

  Fly   238 PQ-VKEDASPSRSKTKALPKRRPSLVDANLKATEARKDAKEEEFILGCNTDPANNSDVNIDGLEL 301
            |: :.:.:|.|:.|.||...::|    ...||.:...|..|
Mouse   169 PRALTKKSSQSKKKKKAFSSQKP----GQSKAVQYPSDVLE------------------------ 205

  Fly   302 DEEVPAESGEDFREINMVGSDVVH-----TDNGEI----YIINSASSEDQNQDSTPEFDQDNGIT 357
                 :.|.|.|.|.:.:.|.||.     .|:.|:    .:.|:..::|..|..|.:..:....:
Mouse   206 -----SASVELFLETSKLSSPVVEQIIQGNDSSELELTSVVENTFPTQDIVQTVTVKRKRRKSQS 265

  Fly   358 SYNIKEDGEIQFSGEK-PEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRK 421
            ...:||......:..| |.|:|     |.|||:...   ||                     |.|
Mouse   266 HCALKEHSMSNIASVKSPYELE-----NAGEELDAR---FS---------------------KAK 301

  Fly   422 ---RSSELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHI----------- 472
               .:...||.:.||..:..  ||...||.:.||||..||.....|..|..||.
Mouse   302 PMCNTCGKVFSEASSLRRHM--RIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGERPYKCELCD 364

  Fly   473 KG------------LKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREV 525
            ||            :..|:....||..|.||.:.:|:||.|...|:|.||:.|..|...|:|...
Mouse   365 KGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQAST 429

  Fly   526 LKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVT 590
            |..|:..|||.|.:.|..|...||..|:|..| .|.|.| .:.:.|.:|.:||.....|::|..:
Mouse   430 LTYHVRRHTGEKPYVCDTCGKAFAVSSSLITH-SRKHTG-EKPYICGICGKSFISSGELNKHFRS 492

  Fly   591 HAGVM-FSCKQCGRQFNDRSAVQRHVTTMHKVKNKLTD------YISETNEFQ 636
            |.|.. |.|:.||..:.|...:::|.|.:|...:|..|      .:||.:..|
Mouse   493 HTGERPFICELCGNSYTDIKNLKKHKTKVHSGTDKNPDCSVDDHAVSEQDSVQ 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	8/31 (26%)
		vATP-synt_E	109..>244	CDD:304907	28/141 (20%)
		RRF	<161..222	CDD:294170	12/62 (19%)
		zf-C2H2_8	454..530	CDD:292531	28/98 (29%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		zf-H2C2_2	497..522	CDD:290200	10/24 (42%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	5/18 (28%)
Mynn	NP_085034.2	BTB	14..115	CDD:279045	25/127 (20%)
		BTB	25..118	CDD:197585	22/119 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..199		12/48 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		5/15 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		0/4 (0%)
		C2H2 Zn finger	304..324	CDD:275368	5/21 (24%)
		zf-C2H2	304..324	CDD:278523	5/21 (24%)
		zf-H2C2_2	316..341	CDD:290200	11/26 (42%)
		C2H2 Zn finger	332..352	CDD:275368	8/19 (42%)
		zf-H2C2_2	345..369	CDD:290200	6/23 (26%)
		C2H2 Zn finger	360..380	CDD:275368	2/19 (11%)
		C2H2 Zn finger	389..409	CDD:275368	8/19 (42%)
		zf-H2C2_2	401..426	CDD:290200	10/24 (42%)
		C2H2 Zn finger	417..437	CDD:275368	6/19 (32%)
		zf-H2C2_2	430..453	CDD:290200	8/22 (36%)
		C2H2 Zn finger	445..465	CDD:275368	8/20 (40%)
		zf-H2C2_2	457..482	CDD:290200	9/26 (35%)
		C2H2 Zn finger	473..493	CDD:275368	6/19 (32%)
		C2H2 Zn finger	501..522	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..548		7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910