DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZBTB3

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001350037.1	Gene:	ZBTB3 / 79842	HGNCID:	22918	Length:	524	Species:	Homo sapiens

Alignment Length:	435	Identity:	86/435 - (19%)
Similarity:	144/435 - (33%)	Gaps:	116/435 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 AAEMHK----RLVKSRLELRAKLTTELRKELAEEVRSEVRKELAEEVRSQVRDDLRNEVSEDIRK 204
            |:.:|.    ::.|.||:.||         |||  ....:||  ||..||:..  ...:|...|.
Human   103 ASYLHMNDIVKVCKRRLQARA---------LAE--ADSTKKE--EETNSQLPS--LEFLSSTSRG 152

  Fly   205 EQLAMLLGELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPSRSKTKA--------LPKRRPSL 261
            .|.::...|...:..:   |.|:......|..:|..:...|.....|:.        |....|.:
Human   153 TQPSLASAETSGHWGK---GEWKGSAAPSPTVRPPDEPPMSSGADTTQPGMEVDAPHLRAPHPPV 214

  Fly   262 VDANLKATEARKDAKEEEF----ILGCNTDPANNSDVNIDGLELDEEVPAESGEDFREINMVGSD 322
            .|.:|.:..:..:.....:    |...:.:|..:.||..:.|.:.|  |.:.|...:
Human   215 ADVSLASPSSSTETIPTNYFSSGISAVSLEPLPSLDVGPESLRVVE--PKDPGGPLQ-------- 269

  Fly   323 VVHTDNGEIYIINSASSEDQNQDSTPEFDQDNGITSYNIKEDGEIQFSGEKPEEIEDVVVFNLGE 387
                   ..|...||.:......|.|                  :......|.|.|.|.|
Human   270 -------GFYPPASAPTSAPAPVSAP------------------VPSQAPAPAEAELVQV----- 304

  Fly   388 EISQEQQVFSFHENVIIVEKEQNDRDEQT--PLKRKRSSELVFKQESSCPQ----PKTGRITD-- 444
                  :|    |.::|.::|.:..|||.  |.:...|...|:..:.|.|:    |....:.:
Human   305 ------KV----EAIVISDEETDVSDEQPQGPERAFPSGGAVYGAQPSQPEAFEDPGAAGLEEVG 359

  Fly   445 -------TVKSFQCHLCP---------VAFPTQKLLTRHHNTHIKGLKSGKGGTL--------KC 485
                   |......||.|         |..|.....:.|...::........|:.        .|
Human   360 PSDHFLPTDPHLPYHLLPGAGQYHRGLVTSPLPAPASLHEPLYLSSEYEAAPGSFGVFTEDVPTC 424

  Fly   486 PSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHM 530
            .:|....||:.:|:||..:||..:|::|..|..|::|...|.||:
Human   425 KTCGKTFSCSYTLRRHATVHTRERPYECRYCLRSYTQSGDLYRHI 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	24/103 (23%)
		RRF	<161..222	CDD:294170	13/60 (22%)
		zf-C2H2_8	454..530	CDD:292531	21/92 (23%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	9/24 (38%)
		C2H2 Zn finger	513..533	CDD:275368	7/18 (39%)
		zf-H2C2_2	526..550	CDD:290200	3/5 (60%)
		C2H2 Zn finger	541..562	CDD:275368
		C2H2 Zn finger	571..591	CDD:275368
		C2H2 Zn finger	598..617	CDD:275368
ZBTB3	NP_001350037.1	BTB_POZ_ZBTB3	1..130	CDD:349632	10/37 (27%)
		PHA03247	<173..401	CDD:223021	46/277 (17%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..461	CDD:372612	9/23 (39%)
		C2H2 Zn finger	452..470	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000