DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and Zfp712

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001159690.1	Gene:	Zfp712 / 78251	MGIID:	1925501	Length:	705	Species:	Mus musculus

Alignment Length:	274	Identity:	84/274 - (30%)
Similarity:	122/274 - (44%)	Gaps:	42/274 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 GITSYNIKEDGEI------------QFSGEKPEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEK 407
            |...|..||.|:.            ..:||||.:.|....||....::|.|::   |..
Mouse   133 GEKPYKCKECGKAFTCSSSLNQHHRIHTGEKPYKCECGKAFNNSSALTQHQRI---HTG------ 188

  Fly   408 EQNDRDEQTPLKRKRSSELVFKQESSC-PQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTH 471
                       :|....|...|..::| .:.:..||....:.::|..|...|.....|::|...|
Mouse   189 -----------ERPYKCEECGKAFNNCSARTRHQRIHTGERPYKCAECGKTFNFPTSLSQHQRIH 242

  Fly   472 IKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGV 536
             .|.|     ..||..|....:|:|.||:|.|||||.||:||.||..:|:....|.:|...|||.
Mouse   243 -TGEK-----PYKCEECGKAFNCSSHLKQHRIIHTGKKPYKCKECSKAFNCSSSLNQHRRIHTGE 301

  Fly   537 KRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQ 600
            ||:.|.:|...|...|.|.|| .|:|.| .:.:||..|.::|.:.|.||||...|.|.. :.|.:
Mouse   302 KRYICEECGKAFNNCSALTQH-QRIHSG-EKPYKCEECGKAFYNCSALSRHQKIHTGEKPYKCAE 364

  Fly   601 CGRQFNDRSAVQRH 614
            ||:.|..||::.:|
Mouse   365 CGKAFIFRSSLSQH 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907
		RRF	<161..222	CDD:294170
		zf-C2H2_8	454..530	CDD:292531	28/75 (37%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		zf-H2C2_2	497..522	CDD:290200	15/24 (63%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	10/23 (43%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..617	CDD:275368	7/17 (41%)
Zfp712	NP_001159690.1	KRAB	5..65	CDD:214630
		KRAB	5..44	CDD:279668
		C2H2 Zn finger	84..103	CDD:275368
		C2H2 Zn finger	111..131	CDD:275368
		zf-H2C2_2	124..148	CDD:290200	5/14 (36%)
		C2H2 Zn finger	139..159	CDD:275368	3/19 (16%)
		C2H2 Zn finger	167..186	CDD:275368	5/21 (24%)
		COG5048	174..603	CDD:227381	73/233 (31%)
		zf-H2C2_2	178..203	CDD:290200	6/44 (14%)
		C2H2 Zn finger	194..214	CDD:275368	4/19 (21%)
		zf-H2C2_2	209..230	CDD:290200	4/20 (20%)
		C2H2 Zn finger	222..242	CDD:275368	5/19 (26%)
		zf-H2C2_2	234..259	CDD:290200	8/30 (27%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		zf-H2C2_2	262..287	CDD:290200	15/24 (63%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	8/20 (40%)
		zf-H2C2_2	318..341	CDD:290200	9/24 (38%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		zf-H2C2_2	346..369	CDD:290200	9/22 (41%)
		C2H2 Zn finger	362..382	CDD:275368	7/17 (41%)
		zf-H2C2_2	374..399	CDD:290200	1/5 (20%)
		C2H2 Zn finger	390..410	CDD:275368
		C2H2 Zn finger	418..438	CDD:275368
		C2H2 Zn finger	446..466	CDD:275368
		C2H2 Zn finger	474..494	CDD:275368
		zf-H2C2_2	486..511	CDD:290200
		C2H2 Zn finger	502..522	CDD:275368
		zf-H2C2_2	514..539	CDD:290200
		C2H2 Zn finger	530..550	CDD:275368
		zf-H2C2_2	542..566	CDD:290200
		C2H2 Zn finger	558..578	CDD:275368
		C2H2 Zn finger	586..606	CDD:275368
		zf-H2C2_2	598..622	CDD:290200
		C2H2 Zn finger	614..634	CDD:275368
		zf-H2C2_2	629..651	CDD:290200
		COG5048	638..>690	CDD:227381
		C2H2 Zn finger	642..662	CDD:275368
		zf-H2C2_2	654..679	CDD:290200
		C2H2 Zn finger	670..690	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910