DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF214

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001341759.1	Gene:	ZNF214 / 7761	HGNCID:	13006	Length:	617	Species:	Homo sapiens

Alignment Length:	612	Identity:	146/612 - (23%)
Similarity:	228/612 - (37%)	Gaps:	171/612 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 YDEDELEFEDSIAFIEVQDKVRKLEDEKWR----EDFKEEQ-----AAEMHKRLVKSRLELRAKL 162
            |.|...|...::..:|..::..|.::||:|    |:|...|     .|:|::
Human    39 YREVMWENYTNVMSVENWNESYKSQEEKFRYLEYENFSYWQGWWNAGAQMYE------------- 90

  Fly   163 TTELRKELAEEVRSEVRKELAEEVRSQVRD--------------DLRNEVSEDIR--KEQLAMLL 211
                .:...|.|:....|:|.::.|||.::              :|..| |:.:|  |.:..|..
Human    91 ----NQNYGETVQGTDSKDLTQQDRSQCQEWLILSTQVPGYGNYELTFE-SKSLRNLKYKNFMPW 150

  Fly   212 GELEVYLTEKKAGRWESLDGS-------------------EPETKPQVKEDASPSRSKTKALPKR 257
            ..||...|: ..||...:.||                   |.|.|..|:....|..   :|||:.
Human   151 QSLETKTTQ-DYGREIYMSGSHGFQGGRYRLGISRKNLSMEKEQKLIVQHSYIPVE---EALPQY 211

  Fly   258 RPSLVDANLKATEARKDAKEEEFILGCN------------------------------------- 285
            ...:...:|     .:|:.||:: .|||
Human   212 VGVICQEDL-----LRDSMEEKY-CGCNKCKGIYYWNSRCVFHKRNQPGENLCQCSICKACFSQR 270

  Fly   286 ----TDPANNSDVNIDGL-ELDEEVPAESGEDFREINMVGSDVVHTDN--GEIYIINSASSEDQN 343
                ..|.|:....:.|. |:|......||..|.:...:| :|.::.|  |:.:...|:....|.
Human   271 SDLYRHPRNHIGKKLYGCDEVDGNFHQSSGVHFHQRVHIG-EVPYSCNACGKSFSQISSLHNHQR 334

  Fly   344 QDSTPEFDQDNGITSYNIKEDGEIQFS-----------GEKPEEIEDVVVFNLGEEISQEQQVFS 397
            ..:..:|        |.|:.|.::..:           ||||.:..     ..|:..:: ..|..
Human   335 VHTEEKF--------YKIECDKDLSRNSLLHIHQRLHIGEKPFKCN-----QCGKSFNR-SSVLH 385

  Fly   398 FHENVIIVEKEQNDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITDTV----KSFQCHLCPVAF 458
            .|:.|...||         |.|.....: .|.|.|:.      ||...|    ||::|..|...|
Human   386 VHQRVHTGEK---------PYKCDECGK-GFSQSSNL------RIHQLVHTGEKSYKCEDCGKGF 434

  Fly   459 PTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQR 523
            ..:..|..|...| .|.|     ..||..|....|.:|.|:.|..:|||.||:.|.||...||:.
Human   435 TQRSNLQIHQRVH-TGEK-----PYKCDDCGKDFSHSSDLRIHQRVHTGEKPYTCPECGKGFSKS 493

  Fly   524 EVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHL 588
            ..|..|...|||.|.::|.:|...|:|:|:|..| .|||.| .:.:|||.|.:.|:|.|.|..|.
Human   494 SKLHTHQRVHTGEKPYKCEECGKGFSQRSHLLIH-QRVHTG-EKPYKCHDCGKGFSHSSNLHIHQ 556

  Fly   589 VTHAGVM-FSCKQCGRQFNDRSAVQRH 614
            ..|.|.. :.|.:||:.|:..||::.|
Human   557 RVHTGEKPYQCAKCGKGFSHSSALRIH 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	36/178 (20%)
		RRF	<161..222	CDD:294170	16/76 (21%)
		zf-C2H2_8	454..530	CDD:292531	25/75 (33%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:290200	11/24 (46%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..617	CDD:275368	7/17 (41%)
ZNF214	NP_001341759.1	KRAB	14..53	CDD:307490	3/13 (23%)
		COG5048	246..587	CDD:227381	98/377 (26%)
		C2H2 Zn finger	260..280	CDD:275368	1/19 (5%)
		C2H2 Zn finger	288..308	CDD:275368	5/19 (26%)
		C2H2 Zn finger	316..336	CDD:275368	4/19 (21%)
		C2H2 Zn finger	345..363	CDD:275368	1/17 (6%)
		C2H2 Zn finger	371..391	CDD:275368	3/25 (12%)
		C2H2 Zn finger	399..419	CDD:275368	5/26 (19%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	483..503	CDD:275368	7/19 (37%)
		C2H2 Zn finger	511..531	CDD:275368	8/20 (40%)
		C2H2 Zn finger	539..559	CDD:275368	8/19 (42%)
		C2H2 Zn finger	567..587	CDD:275368	7/17 (41%)
		C2H2 Zn finger	595..614	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100