DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF135

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_009065.1	Gene:	ZNF135 / 7694	HGNCID:	12919	Length:	682	Species:	Homo sapiens

Alignment Length:	281	Identity:	78/281 - (27%)
Similarity:	124/281 - (44%)	Gaps:	34/281 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 DGEIQFSGEKPEEIEDVVVFN-LGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRSSELV 427
            :|..::|.|..|.:...|.|. :...:.::.|...|.||:.:     |......|:..:|.|...
Human   154 EGHWEWSCESLESLAVPVAFTPVKTPVLEQWQRNGFGENISL-----NPDLPHQPMTPERQSPHT 213

  Fly   428 FKQESSCPQPKTGRITDTV---KSFQCHLCPVAFPTQKLLTRHHNTH-----------IKGLKSG 478
            :.......:|....:..|.   |.::|..|..||.....|..||.||           :||.::.
Human   214 WGTRGKREKPDLNVLQKTCVKEKPYKCQECGKAFSHSSALIEHHRTHTGERPYECHECLKGFRNS 278

  Fly   479 KGGT-----------LKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDT 532
            ...|           .||..|....:..:.|.:|...|||.||::||||..|||.|....:|..|
Human   279 SALTKHQRIHTGEKPYKCTQCGRTFNQIAPLIQHQRTHTGEKPYECSECGKSFSFRSSFSQHERT 343

  Fly   533 HTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-F 596
            |||.|.::|.:|...|.|..:|.||: |:|.| .:.::|..|.::|:|.|.|::|...|.|.. :
Human   344 HTGEKPYECSECGKAFRQSIHLTQHL-RIHTG-EKPYQCGECGKAFSHSSSLTKHQRIHTGEKPY 406

  Fly   597 SCKQCGRQFNDRSAVQRHVTT 617
            .|.:||:.|...:.:.:|..|
Human   407 ECHECGKAFTQITPLIQHQRT 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907
		RRF	<161..222	CDD:294170
		zf-C2H2_8	454..530	CDD:292531	29/97 (30%)
		C2H2 Zn finger	485..505	CDD:275368	4/19 (21%)
		zf-H2C2_2	497..522	CDD:290200	13/24 (54%)
		C2H2 Zn finger	513..533	CDD:275368	9/19 (47%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..617	CDD:275368	5/18 (28%)
ZNF135	NP_009065.1	KRAB	26..85	CDD:214630
		KRAB	26..65	CDD:279668
		zf-C2H2	238..260	CDD:278523	7/21 (33%)
		C2H2 Zn finger	240..260	CDD:275368	7/19 (37%)
		COG5048	264..665	CDD:227381	52/166 (31%)
		C2H2 Zn finger	268..288	CDD:275368	3/19 (16%)
		zf-H2C2_2	280..305	CDD:290200	4/24 (17%)
		C2H2 Zn finger	296..316	CDD:275368	4/19 (21%)
		C2H2 Zn finger	324..344	CDD:275368	9/19 (47%)
		zf-H2C2_2	339..361	CDD:290200	9/21 (43%)
		C2H2 Zn finger	352..372	CDD:275368	8/20 (40%)
		zf-H2C2_2	364..389	CDD:290200	9/26 (35%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		zf-H2C2_2	392..417	CDD:290200	8/24 (33%)
		C2H2 Zn finger	408..428	CDD:275368	6/20 (30%)
		zf-H2C2_2	421..445	CDD:290200	2/7 (29%)
		C2H2 Zn finger	436..456	CDD:275368
		C2H2 Zn finger	464..484	CDD:275368
		zf-H2C2_2	476..501	CDD:290200
		C2H2 Zn finger	492..512	CDD:275368
		zf-H2C2_2	504..529	CDD:290200
		C2H2 Zn finger	520..540	CDD:275368
		zf-H2C2_2	532..557	CDD:290200
		C2H2 Zn finger	548..568	CDD:275368
		zf-H2C2_2	561..585	CDD:290200
		C2H2 Zn finger	576..596	CDD:275368
		C2H2 Zn finger	604..624	CDD:275368
		zf-H2C2_2	619..641	CDD:290200
		C2H2 Zn finger	632..652	CDD:275368
		zf-H2C2_2	644..669	CDD:290200
		C2H2 Zn finger	660..680	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910