Protein Alignment CG31365 and ZNF84

DIOPT Version :10

• Sequence 1: NP_732827.1
• Gene: CG31365 / 42736
• FlyBaseID: FBgn0051365
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_003419.3
• Gene: ZNF84 / 7637
• HGNCID: 13159
• Length: 738
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 130/528 - (24%)
• Similarity: 191/528 - (36%)
• Gaps: 160/528 - (30%)

  Fly   213 ELEVYLTEKKAGRWESLDGSE------------------------PET--------KPQVKEDAS 245
            :|.|..|:|:   |:.||.|:                        |:.        :|.|.:...
Human    12 DLSVDFTQKE---WQLLDPSQKNLYKDVMLENYSSLVSLGYEVMKPDVIFKLEQGEEPWVGDGEI 73

  Fly   246 PSRSKTKALPKRRPSLVDANLKATEARK------------DAKEEEFILGCNTDP--ANNSDVNI 296
            ||....:...      ||.|:...:..:            ||..:.|.|..|..|  .:||:.::
Human    74 PSSDSPEVWK------VDGNMMWHQDNQDKLKIIKRGHECDAFGKNFNLNMNFVPLRKSNSEGDL 132

  Fly   297 DGL----ELDEEVP------AESGEDFREINMVGSDVVHTDNGEIYIINSASSEDQNQ------- 344
            |||    .||..:|      ||| :||   |:..:..:|           :..||.:.
Human   133 DGLILKHHLDLLIPKGDYGKAES-DDF---NVFDNFFLH-----------SKPEDTDTWLKYYDC 182

  Fly   345 DSTPEFDQDNGITSYNIKEDGEIQFS--------GEKP-------EEIEDVV--VFNLGEEISQE 392
            |...|..:.:.|..|:....||..:.        .:||       ..|.|:.  ..|.|:...|:
Human   183 DKYKESYKKSQIIIYHRNRLGEKLYECSECRKRFSKKPSLIKHQSRHIRDIAFGCGNCGKTFPQK 247

  Fly   393 QQVFSFHE-------------NVIIVEKEQNDRDEQTPLKRK------------RSSELV----- 427
            .|..:.|.             .....:|.|....::|....|            |.|.|:
Human   248 SQFITHHRTHTGEKPYNCSQCGKAFSQKSQLTSHQRTHTGEKPYECGECGKAFSRKSHLISHWRT 312

  Fly   428 ---------------FKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIKGLKS 477
                           |.::|:....:  ||....|.|:|..|..||..:..|..||.|| .|.|
Human   313 HTGEKPYGCNECGRAFSEKSNLINHQ--RIHTGEKPFECRECGKAFSRKSQLVTHHRTH-TGTK- 373

  Fly   478 GKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCP 542
                ...|..|.......|.|.||..||||.||::||||..:|.:|..|..|..||||.|.|.|.
Human   374 ----PFGCSDCRKAFFEKSELIRHQTIHTGEKPYECSECRKAFRERSSLINHQRTHTGEKPHGCI 434

  Fly   543 QCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQCGRQFN 606
            ||...|:|||:|..| ...|.| .:...|..|.::|:..|.|.||..||.|.. :.|.:||:.|:
Human   435 QCGKAFSQKSHLISH-QMTHTG-EKPFICSKCGKAFSRKSQLVRHQRTHTGEKPYECSECGKAFS 497

  Fly   607 DRSAVQRH 614
            ::.::..|
Human   498 EKLSLTNH 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		PTZ00121	<110..354	CDD:173412	41/203 (20%)
		zf-C2H2_8	454..542	CDD:464935	36/87 (41%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:463886	14/24 (58%)
		C2H2 Zn finger	513..533	CDD:275368	8/19 (42%)
		zf-H2C2_2	526..550	CDD:463886	12/23 (52%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..617	CDD:275368	5/17 (29%)
ZNF84	NP_003419.3	KRAB	9..68	CDD:214630	10/58 (17%)
		C2H2 Zn finger	209..229	CDD:275368	2/19 (11%)
		C2H2 Zn finger	237..257	CDD:275368	5/19 (26%)
		zf-C2H2	263..285	CDD:395048	2/21 (10%)
		C2H2 Zn finger	265..285	CDD:275368	2/19 (11%)
		zf-H2C2_2	278..302	CDD:463886	2/23 (9%)
		C2H2 Zn finger	293..313	CDD:275368	3/19 (16%)
		COG5048	317..724	CDD:227381	69/199 (35%)
		C2H2 Zn finger	321..341	CDD:275368	3/21 (14%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		C2H2 Zn finger	433..453	CDD:275368	9/20 (45%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	489..509	CDD:275368	5/17 (29%)
		C2H2 Zn finger	517..537	CDD:275368
		C2H2 Zn finger	545..565	CDD:275368
		C2H2 Zn finger	573..593	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368
		C2H2 Zn finger	629..649	CDD:275368
		C2H2 Zn finger	657..677	CDD:275368
		C2H2 Zn finger	685..705	CDD:275368
		C2H2 Zn finger	713..733	CDD:275368