Protein Alignment CG31365 and ZNF28

DIOPT Version :10

• Sequence 1: NP_732827.1
• Gene: CG31365 / 42736
• FlyBaseID: FBgn0051365
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_008900.3
• Gene: ZNF28 / 7576
• HGNCID: 13073
• Length: 718
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 123/522 - (23%)
• Similarity: 199/522 - (38%)
• Gaps: 157/522 - (30%)

  Fly   128 RKLEDE------KWREDFKEEQAAEMHKRLVKSRLELRAKLTTELRKELAEEVRSEVRKELAEEV 186
            :|:|.:      :|:||...:.||.|                                .|:.|..
Human    88 QKIEKDIHGFQFQWKEDETNDHAAPM--------------------------------TEIKELT 120

  Fly   187 RSQVRDDLRNEVSEDIRKEQLAML----LGELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPS 247
            .|..:.|.|:..::.| |:||.:.    |.||.::..|.|.|.         :.:..:...:|.|
Human   121 GSTGQHDQRHAGNKHI-KDQLGLSFHSHLPELHIFQPEGKIGN---------QVEKSINNASSVS 175

  Fly   248 -------RSKTKALPKRRPSLVDANLKATEARKDAKEEEFILGCNTDPANNSDVNIDGLELDEEV 305
                   |.||....|...:.:.::|...:.....:|:.|  .|
Human   176 TSQRICCRPKTHISNKYGNNSLHSSLLTQKRNVHMREKSF--QC--------------------- 217

  Fly   306 PAESGEDFREINMVGSDVVHTDNGEIYIINSASSEDQNQDSTPEFDQDNGITSYNIKEDGEIQFS 370
             .|||:.|                     |.:|...::|           ||....|: .:....
Human   218 -IESGKSF---------------------NCSSLLKKHQ-----------ITHLEEKQ-CKCDVY 248

  Fly   371 GEKPEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRSSELVFKQESSCP 435
            |:         |||       :::..:.|....|.||         |.|.....: :|...:|..
Human   249 GK---------VFN-------QKRYLACHRRSHIDEK---------PYKCNECGK-IFGHNTSLF 287

  Fly   436 QPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKR 500
            ..|.....|  |.::|..|...|..:.    |..|| |.:.:| |...||..|....:|.|.|.:
Human   288 LHKALHTAD--KPYECEECDKVFSRKS----HLETH-KIIYTG-GKPYKCKVCDKAFTCNSYLAK 344

  Fly   501 HMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGN 565
            |.|||||.||:||:||...|::...|.||...|||.|.::|.:|...|::||:|::| .|:|.|
Human   345 HTIIHTGEKPYKCNECGKVFNRLSTLARHRRLHTGEKPYECEECEKVFSRKSHLERH-KRIHTG- 407

  Fly   566 SRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQCGRQFNDRSAVQRHVTTMHKVKNKLTDYI 629
            .:.:||.:|.::|.:.|.|::|.:.|.|.. :.|.:||:.||.:|.:.||    |::......|.
Human   408 EKPYKCKVCDKAFAYNSYLAKHSIIHTGEKPYKCNECGKVFNQQSTLARH----HRLHTAEKPYK 468

  Fly   630 SE 631
            .|
Human   469 CE 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		PTZ00121	<110..354	CDD:173412	40/242 (17%)
		zf-C2H2_8	454..542	CDD:464935	34/87 (39%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:463886	14/24 (58%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:463886	10/23 (43%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	8/18 (44%)
ZNF28	NP_008900.3	KRAB	7..48	CDD:460171
		COG5048	<143..373	CDD:227381	70/329 (21%)
		C2H2 Zn finger	217..237	CDD:275368	9/73 (12%)
		C2H2 Zn finger	245..265	CDD:275368	5/35 (14%)
		SFP1	<264..374	CDD:227516	40/127 (31%)
		C2H2 Zn finger	273..293	CDD:275368	3/20 (15%)
		C2H2 Zn finger	301..321	CDD:275368	7/24 (29%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		COG5048	353..714	CDD:227381	44/124 (35%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..405	CDD:275368	8/20 (40%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		C2H2 Zn finger	441..461	CDD:275368	9/23 (39%)
		C2H2 Zn finger	469..489	CDD:275368	1/2 (50%)
		C2H2 Zn finger	497..517	CDD:275368
		C2H2 Zn finger	525..545	CDD:275368
		C2H2 Zn finger	553..573	CDD:275368
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368