DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and Zbtb49

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_083438.1	Gene:	Zbtb49 / 75079	MGIID:	1922329	Length:	756	Species:	Mus musculus

Alignment Length:	434	Identity:	109/434 - (25%)
Similarity:	165/434 - (38%)	Gaps:	89/434 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 ESLDGSEPE----------------TKPQVKEDASPSRSKTKALPKRRPSLVDANLKATEARKDA 275
            ::..||.||                :|...|:.|.||:......|..|.:..|  |.|.:::...
Mouse   191 DAAGGSCPELPCKQPNHYYKLRTLYSKQYYKQTACPSQVPATQQPLTRSASTD--LAAADSQPPV 253

  Fly   276 KEEEFILGCN--------TDPANNS--DVNIDGLELDEEVPA-----ESGEDFREINMVGSDVVH 325
            :....:|...        ..|..||  |...|.|   .|.||     :.....:::|.:.|
Mouse   254 EGRPAVLETPEHLPSTFVAPPVRNSGNDSEADPL---SEPPAKQMRLKKAMHLKKLNFLKS---- 311

  Fly   326 TDNGEIYIINSASSEDQNQDSTPEFDQDNGITSYN---IKEDGEIQFSGEKPEEIEDVVVFNLGE 387
                           .|:.:.|...:.|||:....   .|||. ::.:|.  :..|:.....||.
Mouse   312 ---------------QQSAECTSHPEPDNGLARREESAAKEDA-VERAGS--QTAEEKGRGELGP 358

  Fly   388 EISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRSSELV---FKQESSCPQPK---TGRITDTV 446
            |.|:|:::..       ......|..:....:::.:.||.   ||..|:....|   ||.
Mouse   359 ESSREEELPG-------APASWEDPSQALQPQKQYACELCGKPFKHPSNLELHKRSHTGE----- 411

  Fly   447 KSFQCHLCPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPF 511
            |.|:|::|...|.....|..|...|     ||:...: |..|..:.:.:..::||:|||:|.||.
Mouse   412 KPFECNICGKHFSQAGNLQTHLRRH-----SGEKPYI-CEICGKRFAASGDVQRHIIIHSGEKPH 470

  Fly   512 KCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHR 576
            .|..|...||....||.|..|||..|...|.:|...|..:..|.:|  ||.....|.:.|..|.:
Mouse   471 LCDTCGRGFSNFSNLKEHKKTHTADKVFTCDECGKSFNMQRKLVKH--RVRHTGERPYSCPACGK 533

  Fly   577 SFNHVSGLSRHLVTHAGVM-FSCKQCGRQFNDRSAVQRHVTTMH 619
            .|.....|.||:.||.|.. :||:.|.:.|. ||||.|....||
Mouse   534 CFGGSGDLRRHVRTHTGEKPYSCEVCSKCFT-RSAVLRRHKRMH 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	6/32 (19%)
		RRF	<161..222	CDD:294170
		zf-C2H2_8	454..530	CDD:292531	23/75 (31%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		zf-H2C2_2	497..522	CDD:290200	11/24 (46%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	10/23 (43%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	8/18 (44%)
Zbtb49	NP_083438.1	BTB	15..118	CDD:279045
		BTB	26..119	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..197		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..290		14/68 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..379		17/96 (18%)
		COG5048	<376..576	CDD:227381	65/213 (31%)
		zf-C2H2	386..408	CDD:278523	6/21 (29%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..425	CDD:290200	8/29 (28%)
		C2H2 Zn finger	416..436	CDD:275368	5/19 (26%)
		zf-H2C2_2	428..452	CDD:290200	7/29 (24%)
		C2H2 Zn finger	444..464	CDD:275368	5/19 (26%)
		zf-H2C2_2	456..481	CDD:290200	11/24 (46%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..508	CDD:290200	9/23 (39%)
		C2H2 Zn finger	500..520	CDD:275368	7/21 (33%)
		zf-H2C2_2	513..535	CDD:290200	7/23 (30%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		zf-H2C2_2	540..565	CDD:290200	10/25 (40%)
		C2H2 Zn finger	556..576	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910