DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31365 and GZF1

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001303941.1	Gene:	GZF1 / 64412	HGNCID:	15808	Length:	711	Species:	Homo sapiens

Alignment Length:	618	Identity:	150/618 - (24%)
Similarity:	235/618 - (38%)	Gaps:	159/618 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YQ-LEKSFLFRQRCQWAEKKLRKHIRLLGL---GKRSRVFSKDPDDYDEDELEFEDSIAFIE--V 123
            || :.|.|:..:....|..|..|.:.|...   |.|:.|:.        :|::..|..:|:|  .
Human    39 YQGVRKDFMAHKAVLAATSKFFKEVFLNEKSVDGTRTNVYL--------NEVQVADFASFLEFVY 95

  Fly   124 QDKVRKLEDEKWREDFKEEQAAEMHKRLVKSRLELRAKLTT--------ELRKELAEEVRSEVRK 180
            ..||:..||.                  |:..||:..||..        :|:|::.|.|..|::.
Human    96 TAKVQVEEDR------------------VQRMLEVAEKLKCLDLSETCFQLKKQMLESVLLELQN 142

  Fly   181 -ELAEEVRSQVRDDLRNEVSEDIRKEQLAMLLGELEVYLTE--KKAGRWESLDGSEPETKPQVKE 242
             ..::||          |||..   .|::..........|:  ..:|..:|||.........:..
Human   143 FSESQEV----------EVSSG---SQVSAAPAPRASVATDGPHPSGLTDSLDYPGERASNGMSS 194

  Fly   243 DASPSRSKTKALPKRR-------PSL--VDANLKATEARKDAKEEEFILGCNTDPANNSDVNIDG 298
            |..|.:||.| |.|::       |.:  ....|...:...:..::::     |..........:|
Human   195 DLPPKKSKDK-LDKKKEVVKPPYPKIRRASGRLAGRKVFVEIPKKKY-----TRRLREQQKTAEG 253

  Fly   299 LELDEEVPAESGEDFREINMVGSDVVHTDNGEIYIINSASSEDQNQDSTPEFDQDNGITSYNIKE 363
            ...|...|.:...|     .||:::......| .....|..|:.::.:.||
Human   254 DVGDYRCPQDQSPD-----RVGTEMEQVSKNE-GCQAGAELEELSKKAGPE-------------- 298

  Fly   364 DGEIQFSGEKPEEIEDVVVFNLGEEISQEQQVF--SFHENVIIVEKEQNDRDEQTPLKRKR---- 422
                   .|:.||.||       ||..:::..|  |..|...:.||        :.||..:
Human   299 -------EEEEEEEED-------EEGEKKKSNFKCSICEKAFLYEK--------SFLKHSKHRHG 341

  Fly   423 -SSELVFKQESSCPQPKTGR---------ITDTVKSFQCHLCPVAFPTQKLLTRH----H----N 469
             ::|:|::.: :|.|....|         :..:.:.|.|.||...|..:|.:.||    |    .
Human   342 VATEVVYRCD-TCGQTFANRCNLKSHQRHVHSSERHFPCELCGKKFKRKKDVKRHVLQVHEGGGE 405

  Fly   470 THIKGLKSGKGGTLK-----------------CPSCALQLSCASSLKRHMIIHTGLKPFKCSECE 517
            .|..| :.|||.:.|                 |..|..:.|..|:||.||.||||.|||.|.||.
Human   406 RHRCG-QCGKGLSSKTALRLHERTHTGDRPYGCTECGARFSQPSALKTHMRIHTGEKPFVCDECG 469

  Fly   518 LSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVS 582
            ..|:|..:|..|...|||.:...|..|...||.|..|:.| .|:|.| |:..||.:|.|:|...:
Human   470 ARFTQNHMLIYHKRCHTGERPFMCETCGKSFASKEYLKHH-NRIHTG-SKPFKCEVCFRTFAQRN 532

  Fly   583 GLSRHLVTHAGVM-FSCKQCGRQFNDRSAVQRH 614
            .|.:|:..|.|.. :.|.|||:||...:|:|||
Human   533 SLYQHIKVHTGERPYCCDQCGKQFTQLNALQRH 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	6/21 (29%)
		vATP-synt_E	109..>244	CDD:304907	29/147 (20%)
		RRF	<161..222	CDD:294170	14/71 (20%)
		zf-C2H2_8	454..530	CDD:292531	33/100 (33%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		zf-H2C2_2	497..522	CDD:290200	15/24 (63%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	10/17 (59%)
GZF1	NP_001303941.1	BTB	21..133	CDD:306997	26/119 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..220		14/70 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..312		18/102 (18%)
		C2H2 Zn finger	319..339	CDD:275368	6/27 (22%)
		C2H2 Zn finger	350..371	CDD:275368	3/21 (14%)
		COG5048	<405..593	CDD:227381	61/164 (37%)
		C2H2 Zn finger	409..429	CDD:275368	5/20 (25%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..513	CDD:275368	8/20 (40%)
		C2H2 Zn finger	521..541	CDD:275368	6/19 (32%)
		C2H2 Zn finger	549..569	CDD:275368	10/17 (59%)
		C2H2 Zn finger	577..597	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000