DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and Zfp109

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_030098682.1	Gene:	Zfp109 / 56869	MGIID:	1929099	Length:	682	Species:	Mus musculus

Alignment Length:	682	Identity:	158/682 - (23%)
Similarity:	239/682 - (35%)	Gaps:	192/682 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KKLRKHIRLLGLGKRSRVFSKDPDDYDEDELEFEDSIAFIEVQDKVRKLEDEKWRED----FKEE 142
            :||||......|.    |||:.|    ........::..::.:..:.||::.....|    |.||
Mouse     2 EKLRKPCGTTVLA----VFSRSP----SSPSLLPRALPCLKEKRTMTKLQEAVTFRDVAVVFSEE 58

  Fly   143 QAAEMHKRLVKSRLELRAKLTTELRKELAEEVRSE-VRKELAEEVRSQVRDDLRNEVSEDIRKEQ 206
            :..                |....:::|..:|..| .|..||  |..||.:.:.|..:..:|...
Mouse    59 ELG----------------LLDAAQRKLYHDVMLENFRNLLA--VGGQVPNKMENLHTTGVRCLS 105

  Fly   207 LAML-LGELEVYLTEKKAGRWESLDGSE-----------------PETKPQVKED---------- 243
            |..| .|.:..:...|.|...|.:..::                 ||..|...:|
Mouse   106 LGQLPCGHMASHDANKLARAPEGVINTQGMVSYFPEQCHFSCHRGPEEPPWASKDNGCLEILTND 170

  Fly   244 --------------ASPSRSKTKALPKR---RPSLVDANLKATEARKDAKEEEFILGCNTDPANN 291
                          |..|.|| |.|.||   :...|...:| |:.|:........:.|.:...||
Mouse   171 HSSITESQKFLSGIAQCSWSK-KHLSKRQNYQKHCVQTPVK-TKPRRLLAPGIDRMSCVSHQDNN 233

  Fly   292 SDVNIDGLELDEEVPAESGEDFREINMVGSDV----VHTD-------NGEIYIINSASSEDQNQD 345
            :        |.:....:|..||.::....|.|    |:|:       ..:...|:..:.|...||
Mouse   234 T--------LHKGDKGQSNSDFDKLTFPVSPVTPHHVYTERKSYKCSKAQEAFIDRPTLELHQQD 290

  Fly   346 ---------STPEFDQDN--------GITSYNIKEDGEIQFS-------------GEKPEEIEDV 380
                     ||.|..:.:        |...|...|.|: .||             ||||...:
Mouse   291 LVGKKSPVRSTYEVSRHSSIQKSVHAGTKRYWCHECGK-AFSQSSALQTHRRVHTGEKPYRCD-- 352

  Fly   381 VVFNLGEEISQ------EQQV---------------FSFHENVIIVEKEQNDRDEQTPLK----- 419
               :.|:..:|      .|::               |.|..|:.|   .|.....:.|.|
Mouse   353 ---SCGKAFTQWSVLHAHQRIHTGEKPYKCGDCGRRFRFSSNLHI---HQRVHTGEKPYKCHVCG 411

  Fly   420 -----------RKRSSELVFKQESSCPQPKTG--------RITDTVKSFQCHLCPVAFPTQKLLT 465
                       |..:.|..:|.: .|.:..|.        |:...||.|.|::|...|.....|.
Mouse   412 KCFRFRFYSHQRVHTGEKPYKCD-ECGKGFTSASNVKVHQRVHTGVKPFCCNVCGKCFSRSFHLH 475

  Fly   466 RHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHM 530
            .|...| .|.|     ..||.:|....|..|||:.|.:||||.||:||.||...|:.....:.|.
Mouse   476 THQRVH-TGEK-----LYKCDACGKAFSQRSSLQVHRLIHTGEKPYKCEECGKGFTSASSFQGHQ 534

  Fly   531 DTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM 595
            ..|||.|...|..|...|::.|.||.| .|:|.| .:.:||..|.::|:..:.|..|..||.|..
Mouse   535 RVHTGEKPFHCDVCGKDFSRSSYLQIH-QRMHTG-EKPYKCDSCGKAFSQRAHLQVHQRTHTGEK 597

  Fly   596 -FSCKQCGRQFNDRSAVQRHVTTMHKVKNKLT 626
             |.|::||::|..||.:..| ..:||.:...|
Mouse   598 PFKCEECGKEFRQRSGLSSH-QIVHKEEKPYT 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	2/3 (67%)
		vATP-synt_E	109..>244	CDD:304907	28/181 (15%)
		RRF	<161..222	CDD:294170	15/62 (24%)
		zf-C2H2_8	454..530	CDD:292531	26/75 (35%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	14/24 (58%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..617	CDD:275368	7/18 (39%)
Zfp109	XP_030098682.1	KRAB	46..86	CDD:366587	11/57 (19%)
		COG5048	<232..477	CDD:227381	50/262 (19%)
		C2H2 Zn finger	323..343	CDD:275368	4/20 (20%)
		C2H2 Zn finger	351..371	CDD:275368	3/24 (13%)
		COG5048	<361..617	CDD:227381	75/267 (28%)
		C2H2 Zn finger	379..399	CDD:275368	5/22 (23%)
		C2H2 Zn finger	407..425	CDD:275368	1/17 (6%)
		C2H2 Zn finger	433..453	CDD:275368	3/20 (15%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	5/19 (26%)
		C2H2 Zn finger	545..565	CDD:275368	8/20 (40%)
		C2H2 Zn finger	573..593	CDD:275368	5/19 (26%)
		C2H2 Zn finger	601..621	CDD:275368	7/20 (35%)
		C2H2 Zn finger	629..649	CDD:275368	158/682 (23%)
		C2H2 Zn finger	657..677	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100