DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and Zfp235

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001347394.1	Gene:	Zfp235 / 56525	MGIID:	1929117	Length:	772	Species:	Mus musculus

Alignment Length:	616	Identity:	142/616 - (23%)
Similarity:	236/616 - (38%)	Gaps:	139/616 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SKDPDDYDED----ELEFEDSIAFIEVQDKVRKLEDEKW-REDFKEEQAAEMH--KRLVKSRLEL 158
            :::|....||    |....|..:..|.|:.:.......| :.||.|....|..  :.|||::.:|
Mouse   183 TEEPLQVSEDNGCLESLTSDHSSITENQEFLSGRAQSSWSKTDFSERWNHEKRCTQTLVKTKSQL 247

  Fly   159 RAKLTTELRKELAEEVRSEVRKELAEEVRSQVRDDLRNEVSEDIRKEQLAM---LLGELEVYLTE 220
            .| |..::...::.:..:.:.|              |::|......:|:..   .|.:..|| ||
Mouse   248 LA-LGVDILNCISHQDNNILHK--------------RDKVPSSGDCDQVIFPMACLTQSPVY-TE 296

  Fly   221 KKA-----GRWESLDGSEPETKPQVKEDASP------SRSKTKAL------PKR---------RP 259
            :||     |:...:|....||:..:..:.||      ..|.|.::      |.|         :.
Mouse   297 QKAYQCNTGQDAFIDSPSQETQQVLLGNKSPVHGTYEDTSYTSSVIQQSVHPGRKRYWCQECGKA 361

  Fly   260 SLVDANLKATEARKDAKEEEFIL-----------------------------GCNTDPANNSDVN 295
            ....:||: |..|....|:.:..                             .|....:.::|:|
Mouse   362 FSQSSNLQ-THQRVHTGEKPYTCPECGKSFNQSSHLYAHLPIHTGEKPYCCDNCGKGFSRSTDLN 425

  Fly   296 IDGLELDEEVPAE---SGEDF-REINMVGSDVVHT--------DNGEIYIINSASSEDQ--NQDS 346
            |.......|.|.:   .|:.| :..::...:.:||        |.|:.:..:|.....|  :.:.
Mouse   426 IHCRVHTGEKPYKCEVCGKGFTQRSHLQAHERIHTGEKPYKCGDCGKCFSCSSNLHTHQRVHTEE 490

  Fly   347 TPEFDQDNG---ITSYNIKEDGEIQFSGEKPEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEKE 408
            .|....:.|   ..|:|:.....:. :||||.:.|:     .|:..|.... |..|:.|...||
Mouse   491 KPYKCDECGKRFSLSFNLHSHQRVH-TGEKPYKCEE-----CGKGFSSASS-FQSHQRVHTGEK- 547

  Fly   409 QNDRDEQTP----LKRKRSSELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHN 469
                    |    :..|..|:..:.|...       |:....|.::|.:|...|.....|..|..
Mouse   548 --------PFCCSVCGKGFSQSSYFQAHQ-------RVHTGEKPYRCDVCGKRFNWSLNLHNHQR 597

  Fly   470 THIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHT 534
            .|     :|: ...||..|....|.||:|:.|..:|||.|||:|:.|:..|||...|:.|...||
Mouse   598 VH-----TGE-RPYKCEECGKGFSQASNLQAHQSVHTGEKPFRCNACQKRFSQASHLQAHQRVHT 656

  Fly   535 GVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSC 598
            |.:.::|..|...|:|:||||.| ..:|.| .:..||..|.:.|:..:||:.|...|.|.. ::|
Mouse   657 GERPYKCDTCGKAFSQRSNLQVH-QIIHTG-EKPFKCEECGKEFSWSAGLTAHQRVHTGEKPYTC 719

  Fly   599 KQCGRQFNDRSAVQRHVTTMHKVKNKLTDYI 629
            :|||:.|:..|    |..|..:|......||
Mouse   720 QQCGKGFSQAS----HFHTHQRVHTGERPYI 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	32/149 (21%)
		RRF	<161..222	CDD:294170	10/63 (16%)
		zf-C2H2_8	454..530	CDD:292531	26/75 (35%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	11/24 (46%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	7/18 (39%)
Zfp235	NP_001347394.1	KRAB	8..48	CDD:307490
		COG5048	355..696	CDD:227381	86/372 (23%)
		C2H2 Zn finger	355..375	CDD:275368	4/20 (20%)
		C2H2 Zn finger	383..403	CDD:275368	0/19 (0%)
		C2H2 Zn finger	411..431	CDD:275368	4/19 (21%)
		C2H2 Zn finger	439..459	CDD:275368	2/19 (11%)
		C2H2 Zn finger	467..487	CDD:275368	4/19 (21%)
		C2H2 Zn finger	495..515	CDD:275368	3/19 (16%)
		C2H2 Zn finger	523..543	CDD:275368	5/25 (20%)
		C2H2 Zn finger	551..571	CDD:275368	4/26 (15%)
		C2H2 Zn finger	579..599	CDD:275368	5/19 (26%)
		C2H2 Zn finger	607..627	CDD:275368	7/19 (37%)
		C2H2 Zn finger	635..655	CDD:275368	7/19 (37%)
		C2H2 Zn finger	663..683	CDD:275368	9/20 (45%)
		SFP1	<685..768	CDD:227516	21/67 (31%)
		C2H2 Zn finger	691..711	CDD:275368	6/19 (32%)
		C2H2 Zn finger	719..739	CDD:275368	8/23 (35%)
		C2H2 Zn finger	747..767	CDD:275368	142/616 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100